Azenosertib (ZN-c3) 是一种口服有效的 Wee1 选择性抑制剂 (IC50=3.9 nM)。Azenosertib 具有抗肿瘤活性。

RP-6306是一种选择性的PKMYT1抑制剂，具有抗癌活性，能有效调节细胞周期相关信号通路。

MK-1775（Adavosertib (AZD-1775)具有强效的Wee1抑制作用，IC50为5.2 nM。

PD0166285 inhibits Wee1 and Chk1 at nanomolar concentrations and can hinder G2 checkpoint.

Flavokawain A, a natural product isolated and purified from the roots of Piper methysticum with anti-tumor and anti-inflammatory activities, can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.

WEE1-IN-5是一种有效的WEE1抑制剂，能够消除G2检查点，增加癌细胞对DNA损伤剂的敏感性，适用于抗癌研究。

PD 166285 inhibited Src nonreceptor tyrosine kinase, fibroblast growth factor receptor-1, epidermal growth factor receptor and platelet-derived growth factor receptor beta subunit (PDGFR-beta), tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 8.4 +/- 2.3 nM (n = 6), 39.3 +/- 2.8 nM (n = 16), 87.5 +/- 13.7 nM (n = 6) and 98.3 +/- 7.9 nM (n = 16), respectively.

PD 407824 is a potent and selective inhibitor of checkpoint kinases Chk1 and Wee1 with IC50s of 47 and 97 nM respectively.