TAO Kinase inhibitor 1
TAO Kinase inhibitor 1 is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. It inhibits TAOK phosphorylation and activation of JNK in vitro, and also prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line.