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首页 / 抑制剂/激动剂 / MAPK/ERK Pathway / TAOK / TAO Kinase inhibitor 1

TAO Kinase inhibitor 1 {[allProObj[0].p_purity_real_show]}

货号：A1000438 同义名： CP 43;Compound 43 TAO Kinase Inhibitor

TAO Kinase inhibitor 1是一种选择性的ATP竞争性TAOK激酶抑制剂，对TAOK1（IC50 11 nM）和TAOK2（IC50 15 nM）具有较强的抑制作用，能延迟有丝分裂并增加SKBR3乳腺癌细胞系中的有丝分裂细胞死亡。

TAO Kinase inhibitor 1 化学结构 CAS号：850467-66-2
TAO Kinase inhibitor 1 化学结构
CAS号：850467-66-2
TAO Kinase inhibitor 1 3D分子结构
CAS号：850467-66-2
TAO Kinase inhibitor 1 化学结构 CAS号：850467-66-2
TAO Kinase inhibitor 1 3D分子结构 CAS号：850467-66-2
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TAO Kinase inhibitor 1 纯度/质量文件 产品仅供科研

货号：A1000438 标准纯度： {[allProObj[0].p_purity_real_show]}
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TAO Kinase inhibitor 1 生物活性

描述 The TAO (for thousand-and-one amino acids) protein kinases activate p38 mitogen-activated protein (MAP) kinase cascades in vitro and in cells by phosphorylating the MAP/ERK kinases (MEKs) 3 and 6. TAO protein kinases relay signals from carbachol through heterotrimeric G proteins to the p38 MAP kinase, which then activates TCFs in the nucleus[1]. TAO Kinase inhibitor 1 is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively[2]. TAO inhibitor 1 reduced tau phosphorylation on T123 and T427 (Identified in AD brains) and also on additional pathological sites (S262/S356 and S202/T205/S208) in vitro and in cell models. It is also decreased tau phosphorylation in differentiated primary cortial neurons without affecting markers of synapse and neuron health. Furthermore, the activity of TAOK decreased tau phosphorylation in induced pluripotent stem cell derived neurons from FTLD patients, as well as cortical neurons from a transgenic mouse model of tauopathy (Tau3 mice)[3].

TAO Kinase inhibitor 1 参考文献

[1]Zhu Chen,et al. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J Biol Chem. 2003. 278(25), 22278-83.

[2]Chuay-Yeng Koo,et al. Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells. Mol Cancer Ther. 2017. 16(1), 2410-2421.

[3]Giacomini, C., Koo, C.Y., Yankova, N. et al. A new TAOO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta neuropahtol commun. 2018. 37(6).

TAO Kinase inhibitor 1 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.00mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL

TAO Kinase inhibitor 1 技术信息

CAS号850467-66-2
分子式C25H24N2O2
分子量 384.47
别名 CP 43;Compound 43 TAO Kinase Inhibitor
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Room Temperature
溶解方案

DMSO: 60 mg/mL(156.06 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

Tags: TAO Kinase inhibitor 1 | 850467-66-2 | CP 43 | TAO Kinase inhibitor1 | TAO Kinase inhibitor-1 | CP43 | CP-43 | MAP3K | MAP kinase kinase kinase, MEKK, MAPKKK | TAOK Inhibitor | MAPK/ERK Pathway | MAP3K | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | TAO Kinase inhibitor 1 纯度/质量文件 | TAO Kinase inhibitor 1 生物活性 | TAO Kinase inhibitor 1 参考文献 | TAO Kinase inhibitor 1 实验方案 | TAO Kinase inhibitor 1 技术信息

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