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plantamajoside/大车前苷 {[allProObj[0].p_purity_real_show]}

货号:A106743 同义名: 车前子甙 / Y0160; C10485

plantamajoside是一种从 Plantago depressa Willd. 草本植物中提取的天然产物,具有抗肝毒性、抗炎、镇痛活性,改善性功能和抗氧化作用。

plantamajoside/大车前苷 化学结构 CAS号:104777-68-6
plantamajoside/大车前苷 化学结构
CAS号:104777-68-6
plantamajoside/大车前苷 3D分子结构
CAS号:104777-68-6
plantamajoside/大车前苷 化学结构 CAS号:104777-68-6
plantamajoside/大车前苷 3D分子结构 CAS号:104777-68-6
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plantamajoside/大车前苷 纯度/质量文件 产品仅供科研

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plantamajoside/大车前苷 生物活性

描述 Plantamajoside (PMS) is a phenylpropanoid glycoside isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside ameliorated the lung injury that was induced by LPS. Plantamajoside suppressed the production of IL-1β, IL-6 and TNF-α in a dose-dependent manner. Plantamajoside inhibited the phosphorylation of IκBα, p65, p38, JNK and ERK. Plantamajoside has protective effect on LPS-induced ALI (acute lung injury) in mice and in RAW264.7 cells[3]. In vitro, PMS inhibited the ISO(isoproterenol)-induced increase in H9c2 cell surface area and the mRNA expression of ANP, BNP and Myh7. In vivo, PMS improved the ISO-induced decrease in cardiac function, inhibited the increase in cardiac anatomical parameters and alleviated the histopathological changes in cardiac tissues[4]. PMS inhibited the invasion, migration and viability of malignant melanoma cells. In addition, PMS induced apoptosis by regulating the expression levels of apoptotic-related genes and the activation of the PI3K/AKT signaling pathway, thereby exerting anti-malignant melanoma effects[5]. Plantamajoside decreased the production of PGE2, NO, IL-6, and IL-8 in LPS-stimulated HGFs. LPS-induced NF-κB p65 and IκB phosphorylation were also suppressed by plantamajoside. Furthermore, plantamajoside inhibited LPS-induced PI3K and AKT phosphorylation[6]. PMS protected against myocardial I/R injury via attenuating oxidative stress, inflammatory response and apoptosis[7].

plantamajoside/大车前苷 参考文献

[1]Jung HY, Seo DW, et al. Nephroprotection of plantamajoside in rats treated with cadmium. Environ Toxicol Pharmacol. 2015 Jan;39(1):125-36.

[2]Sun Q, Geng F, et al. [Qualitative and quantitative analysis of plantamajoside in Plantaginis Herba] . Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2095-8. Chinese.

[3]Wu H, Zhao G, Jiang K, Chen X, Zhu Z, Qiu C, Li C, Deng G. Plantamajoside ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation. Int Immunopharmacol. 2016 Jun;35:315-322

[4]Shang L, Pin L, Zhu S, Zhong X, Zhang Y, Shun M, Liu Y, Hou M. Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway. Chem Biol Interact. 2019 Jul 1;307:21-28

[5]Wang Y, Liu M, Chen S, Wu Q. Plantamajoside represses the growth and metastasis of malignant melanoma. Exp Ther Med. 2020 Mar;19(3):2296-2302

[6]Liu F, Huang X, He JJ, Song C, Peng L, Chen T, Wu BL. Plantamajoside attenuates inflammatory response in LPS-stimulated human gingival fibroblasts by inhibiting PI3K/AKT signaling pathway. Microb Pathog. 2019 Feb;127:208-211

[7]Zeng G, An H, Fang D, Wang W, Han Y, Lian C. Plantamajoside protects H9c2 cells against hypoxia/reoxygenation-induced injury through regulating the akt/Nrf2/HO-1 and NF-κB signaling pathways. J Recept Signal Transduct Res. 2020 Dec 22:1-8

plantamajoside/大车前苷 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.56mL

0.31mL

0.16mL

7.81mL

1.56mL

0.78mL

15.61mL

3.12mL

1.56mL

plantamajoside/大车前苷 技术信息

CAS号104777-68-6
分子式C29H36O16
分子量 640.59
SMILES Code O=C(O[C@@H]1[C@@H](CO)O[C@@H](OCCC2=CC=C(O)C(O)=C2)[C@H](O)[C@H]1O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)/C=C/C4=CC=C(O)C(O)=C4
MDL No. MFCD20527298
别名 车前子甙 ;Y0160; C10485
运输蓝冰
InChI Key KFEFLPDKISUVNR-QJEHNBJNSA-N
Pubchem ID 5281788
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C

溶解方案

DMSO: 105 mg/mL(163.91 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
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