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plantamajoside

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Chemical Structure| 104777-68-6 同义名 : 车前子甙 ;Y0160;C10485
CAS号 : 104777-68-6
货号 : A106743
分子式 : C29H36O16
纯度 : 99%+
分子量 : 640.587
MDL号 : MFCD20527298
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(163.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Plantamajoside (PMS) is a phenylpropanoid glycoside isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside ameliorated the lung injury that was induced by LPS. Plantamajoside suppressed the production of IL-1β, IL-6 and TNF-α in a dose-dependent manner. Plantamajoside inhibited the phosphorylation of IκBα, p65, p38, JNK and ERK. Plantamajoside has protective effect on LPS-induced ALI (acute lung injury) in mice and in RAW264.7 cells[3]. In vitro, PMS inhibited the ISO(isoproterenol)-induced increase in H9c2 cell surface area and the mRNA expression of ANP, BNP and Myh7. In vivo, PMS improved the ISO-induced decrease in cardiac function, inhibited the increase in cardiac anatomical parameters and alleviated the histopathological changes in cardiac tissues[4]. PMS inhibited the invasion, migration and viability of malignant melanoma cells. In addition, PMS induced apoptosis by regulating the expression levels of apoptotic-related genes and the activation of the PI3K/AKT signaling pathway, thereby exerting anti-malignant melanoma effects[5]. Plantamajoside decreased the production of PGE2, NO, IL-6, and IL-8 in LPS-stimulated HGFs. LPS-induced NF-κB p65 and IκB phosphorylation were also suppressed by plantamajoside. Furthermore, plantamajoside inhibited LPS-induced PI3K and AKT phosphorylation[6]. PMS protected against myocardial I/R injury via attenuating oxidative stress, inflammatory response and apoptosis[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.56mL

0.31mL

0.16mL

7.81mL

1.56mL

0.78mL

15.61mL

3.12mL

1.56mL
参考文献

[1]Jung HY, Seo DW, et al. Nephroprotection of plantamajoside in rats treated with cadmium. Environ Toxicol Pharmacol. 2015 Jan;39(1):125-36.

[2]Sun Q, Geng F, et al. [Qualitative and quantitative analysis of plantamajoside in Plantaginis Herba] . Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2095-8. Chinese.

[3]Wu H, Zhao G, Jiang K, Chen X, Zhu Z, Qiu C, Li C, Deng G. Plantamajoside ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation. Int Immunopharmacol. 2016 Jun;35:315-322

[4]Shang L, Pin L, Zhu S, Zhong X, Zhang Y, Shun M, Liu Y, Hou M. Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway. Chem Biol Interact. 2019 Jul 1;307:21-28

[5]Wang Y, Liu M, Chen S, Wu Q. Plantamajoside represses the growth and metastasis of malignant melanoma. Exp Ther Med. 2020 Mar;19(3):2296-2302

[6]Liu F, Huang X, He JJ, Song C, Peng L, Chen T, Wu BL. Plantamajoside attenuates inflammatory response in LPS-stimulated human gingival fibroblasts by inhibiting PI3K/AKT signaling pathway. Microb Pathog. 2019 Feb;127:208-211

[7]Zeng G, An H, Fang D, Wang W, Han Y, Lian C. Plantamajoside protects H9c2 cells against hypoxia/reoxygenation-induced injury through regulating the akt/Nrf2/HO-1 and NF-κB signaling pathways. J Recept Signal Transduct Res. 2020 Dec 22:1-8