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头孢布烯二水合物 /Ceftibuten dihydrate {[allProObj[0].p_purity_real_show]}

货号：A188772 同义名： Sch-39720 dihydrate;Ceftibuten (hydrate)

Ceftibuten Dihydrate a semisynthetic, β-lactamase-stable, third-generation cephalosporin with antibacterial activity.

Ceftibuten dihydrate 化学结构 CAS号：118081-34-8
Ceftibuten dihydrate 化学结构
CAS号：118081-34-8
Ceftibuten dihydrate 3D分子结构
CAS号：118081-34-8
Ceftibuten dihydrate 化学结构 CAS号：118081-34-8
Ceftibuten dihydrate 3D分子结构 CAS号：118081-34-8
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Ceftibuten dihydrate 纯度/质量文件 产品仅供科研

货号：A188772 标准纯度： {[allProObj[0].p_purity_real_show]}
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Ceftibuten dihydrate 生物活性

描述 Ceftibuten (Dihydrate), an oral expanded-spectrum cephalosporin, has a broad spectrum of activity against many gram-negative and selected gram-positive organisms. Ceftibuten is stable to hydrolysis by many common beta-lactamases[3]. Ceftibuten displayed high activity against Haemophilus influenzae and Branhamella catarrhalis. There was reduced activity against Streptococcus pneumoniae (MIC90 16 mg/l). The protein binding of ceftibuten was 77% and the primary target site PBP3[4]. Moreover, the synergistic combination of ceftibuten plus amoxicillin-clavulanic acid may be an option for oral treatment of UTIs (urinary tract infection) caused by ESBL (extended-spectrum β-lactamase) producing E. coli or K. pneumoniae[5].

Ceftibuten dihydrate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01604824 Hypercholesterolemia Phase 2 Unknown September 2016 United States, Utah ... 展开 >> Salt Lake City, Utah, United States France Lille, Cedex, France Nante, Cedex, France Paris, France 收起 <<
NCT02746510 Schizophrenia Not Applicable Recruiting August 2019 France ... 展开 >> CH Le Vinatier Recruiting BRON Cedex, Rhône-Alpes, France, 69678 Contact: POISSON ALICE, PH    0437915163    alice.poisson@ch-le-vinatier.fr    Contact: VIAL VERONIQUE    0437915531    veronique.vial@ch-le-vinatier.fr 收起 <<
NCT02899676 Neural Bases of Arithmetic Pro... 展开 >>cessing 收起 << Not Applicable Unknown May 2017 France ... 展开 >> Médecine nucléaire, Groupement Hospitalier Est Recruiting BRON cedex, France, 69677 Contact: Christian SCHEIBER, MD, PhD    +33 4 72 68 49 61    christian.scheiber@chu-lyon.fr    Principal Investigator: Christian SCHEIBER, MD, PhD 收起 <<

Ceftibuten dihydrate 参考文献

[1]Lo JY, Ho KM, et al. Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. Antimicrob Agents Chemother. 2008 Oct;52(10):3564-7.

[2]Wise R, Andrews JM, et al. Ceftibuten--in-vitro activity against respiratory pathogens, beta-lactamase stability and mechanism of action. J Antimicrob Chemother, 1990. 26(2): p. 209-213.

[3]Guay DR. Ceftibuten: a new expanded-spectrum oral cephalosporin. Ann Pharmacother. 1997 Sep;31(9):1022-33.

[4]Wise R, Andrews JM, Ashby JP, Thornber D. Ceftibuten--in-vitro activity against respiratory pathogens, beta-lactamase stability and mechanism of action. J Antimicrob Chemother. 1990 Aug;26(2):209-13.

[5]Cohen Stuart J, Leverstein-Van Hall M, Kortmann W, Verlind J, Mulder F, Scharringa J, Fluit A, Ekkelenkamp M. Ceftibuten plus amoxicillin-clavulanic acid for oral treatment of urinary tract infections with ESBL producing E. coli and K. pneumoniae: a retrospective observational case-series. Eur J Clin Microbiol Infect Dis. 2018 Oct;37(10):2021-2025.

Ceftibuten dihydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.40mL

4.48mL

2.24mL

Ceftibuten dihydrate 技术信息

CAS号118081-34-8
分子式C15H18N4O8S2
分子量 446.455
别名 Sch-39720 dihydrate;Ceftibuten (hydrate);SCH 39720
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C
溶解度

DMSO: 105 mg/mL(235.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Ceftibuten dihydrate | 118081-34-8 | Sch-39720 dihydrate | Beta-lactamase | Anti-infection | Beta-lactamase | Bacterial | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ceftibuten dihydrate 纯度/质量文件 | Ceftibuten dihydrate 生物活性 | Ceftibuten dihydrate 临床数据 | Ceftibuten dihydrate 参考文献 | Ceftibuten dihydrate 实验方案 | Ceftibuten dihydrate 技术信息

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