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快速发货 顺丰冷链运输,1-2 天到达
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免费溶解
描述 | WWL70 is identified as a selective inhibitor of the alpha/beta hydrolase domain 6 (ABHD6), exhibiting an IC50 of 70 nM[1]. One hour following treatment with WWL70 at a concentration of 10 μM, there is a 20% increase in 2-Arachidonoylglycerol levels compared to untreated cells. WWL70, at concentrations of 1 μM or 10 μM, entirely prevents LPS-induced elevation of PGE2. It also diminishes the LPS-stimulated mRNA upregulation of mPGES-1 and mPGES-2. The IC50 for WWL70 in the inhibition of PGE2 synthesis is approximately 100 nM[2]. |
Animal study | Post-treatment with WWL70 at a dosage of 5 mg/kg shows no significant effect, whereas a 10 mg/kg dosage markedly enhances performance. WWL70 treatment dose-dependently improves motor coordination in mice with traumatic brain injury (TBI). The time before falling increases in animals treated with 5 mg/kg WWL70 from 74.92±4.8 to 99.57±5.21 on day 3 (p<0.01) and from 87.32±4.42 to 100.14±3.56 on day 7 (p<0.05) post-injury, compared to the vehicle-TBI groups. With a 10 mg/kg dosage, WWL70 treatment begins to enhance motor coordination from day 1 post-injury. WWL70 treatment fully restores the ability of TBI mice to continuously alternate arms during Y maze exploration, achieving a success rate of 69.67±4.98%[3]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.29mL 0.46mL 0.23mL |
11.43mL 2.29mL 1.14mL |
22.86mL 4.57mL 2.29mL |
CAS号 | 947669-91-2 |
分子式 | C27H23N3O3 |
分子量 | 437.49 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 16 mg/mL(36.57 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |