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首页 / 抑制剂/激动剂 / 干细胞 / sFRP-1 / WAY 316606

WAY 316606 {[allProObj[0].p_purity_real_show]}

货号：A333983

WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM.

WAY 316606 化学结构 CAS号：915759-45-4
WAY 316606 化学结构
CAS号：915759-45-4
WAY 316606 3D分子结构
CAS号：915759-45-4
WAY 316606 化学结构 CAS号：915759-45-4
WAY 316606 3D分子结构 CAS号：915759-45-4
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WAY 316606 纯度/质量文件 产品仅供科研

货号：A333983 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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WAY 316606 生物活性

描述 The Wnt signaling pathway is activated by secreted Wnt glycoproteins and regulates various biological processes, including skeletal development. Secreted frizzled-related protein-1 (sFRP-1) is a negative regulator or an antagonist of the Wnt signaling pathway. WAY-316606 is identified as an inhibitor of sFRP-1 with IC50 value of 0.5 μM[3]. WAY-316606 enhanced total bone area up to 60% in a dose-dependent manner when tested in a neonatal murine ex vivo calvarial assay[3]. WAY-316606 treated rat mandibles (1 mM, 10 uL, on alternate days for 7 days) showed a substantial gain of interradicular bone mass near the inhibitor application site compared to rat mandibles treated with a vehicle control, in MicroCT analysis[4]. Differentiating periodontal ligament cells cultured with 1 and 2 uM of WAY-316606 showed increased alkaline phosphatase activity and enhanced mineral deposits in a dose dependent manner compared to cells cultured with induction media alone[4].
作用机制 WAY-316606 inhibits sFRP-1 perhaps via the netrin domain.

WAY 316606 动物研究

Dose Rat: 2 mg/kg[2] (i.v.)
Administration i.v.

WAY 316606 参考文献

[1]Moore WJ, Kern JC, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem. 2009 Jan 8;52(1):105-16.

[2]Bodine PV, Stauffer B, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44(6):1063-8.

[3]Moore WJ, Kern JC, Bhat R, Commons TJ, Fukayama S, Goljer I, Krishnamurthy G, Magolda RL, Nogle L, Pitts K, Stauffer B, Trybulski EJ, Welmaker GS, Wilson M, Bodine PV. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem. 2009 Jan 8;52(1):105-16. doi: 10.1021/jm801144h. PMID: 19072540.

[4]Gopinathan G, Foyle D, Luan X, Diekwisch TGH. The Wnt Antagonist SFRP1: A Key Regulator of Periodontal Mineral Homeostasis. Stem Cells Dev. 2019 Aug 1;28(15):1004-1014. doi: 10.1089/scd.2019.0124. Epub 2019 Jul 22. PMID: 31215318; PMCID: PMC6661921.

WAY 316606 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.15mL

2.23mL

1.11mL

22.30mL

4.46mL

2.23mL

WAY 316606 技术信息

CAS号915759-45-4
分子式C18H19F3N2O4S2
分子量 448.48
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 105 mg/mL(234.12 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: WAY 316606 | 915759-45-4 | WAY316606 | WAY-316606 | sFRP-1 Inhibitor | Stem Cell/Wnt | sFRP-1 | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | WAY 316606 纯度/质量文件 | WAY 316606 生物活性 | WAY 316606 动物研究 | WAY 316606 参考文献 | WAY 316606 实验方案 | WAY 316606 技术信息

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