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伐昔洛韦盐酸盐 /Valacyclovir hydrochloride {[allProObj[0].p_purity_real_show]}

货号:A199102 同义名: 盐酸伐昔洛韦 / Valaciclovir hydrochloride;L-Valacyclovir (hydrochloride)

Valacyclovir HCl is a Herpes Simplex Virus and Herpes Zoster Virus nucleoside analog DNA polymerase inhibitor as it is a synthetic purine nucleoside analogue.

Valacyclovir hydrochloride 化学结构 CAS号:124832-27-5
Valacyclovir hydrochloride 化学结构
CAS号:124832-27-5
Valacyclovir hydrochloride 3D分子结构
CAS号:124832-27-5
Valacyclovir hydrochloride 化学结构 CAS号:124832-27-5
Valacyclovir hydrochloride 3D分子结构 CAS号:124832-27-5
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Valacyclovir hydrochloride 纯度/质量文件 产品仅供科研

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Valacyclovir hydrochloride 生物活性

描述 Valacyclovir Hydrochloride is the hydrochloride salt of valacyclovir. Valacyclovir is an acyclovir prodrug that, after metabolization, inhibits viral DNA replication. It is used in the management of herpes simplex and varicella zoster infections, as well as prophylactically for human cytomegalovirus infections[3]. Valacyclovir is safe and effective in the therapy of patients with herpes simplex and herpes zoster and may be useful in other viral infections[4]. Valacyclovir has similar efficacy to acyclovir in the episodic and suppressive treatment of genital herpes. In addition, valacyclovir is also indicated in the reduction of the sexual transmission of herpes simplex virus infection and for the treatment of herpes labialis. In herpes zoster, valacyclovir is more effective than acyclovir or placebo (and as equally effective as famciclovir) in shortening the length and severity of herpes zoster-associated pain and postherpetic neuralgia. Valacyclovir has an acceptable safety profile in patients with herpes simplex and herpes zoster[5]. Nucleoside analogues against herpes simplex virus (HSV) have been shown to suppress shedding of HSV type 2 (HSV-2) on genital mucosal surfaces and may prevent sexual transmission of HSV. Once-daily suppressive therapy with valacyclovir significantly reduces the risk of transmission of genital herpes among heterosexual, HSV-2-discordant couples[6].

Valacyclovir hydrochloride 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00946556 Herpes Simplex Type Two Infect... 展开 >>ion HIV Infections 收起 << Not Applicable Completed - Canada, Ontario ... 展开 >> Women's Health In Women's Hands Toronto, Ontario, Canada 收起 <<
NCT03131037 Lung Cancer Phase 1 Recruiting May 2022 United States, Pennsylvania ... 展开 >> University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Brenda Horn    215-590-4202    brenda.horn@uphs.upenn.edu    Principal Investigator: Sunil Singhal 收起 <<
NCT01997190 Malignant Pleural Effusion ... 展开 >> Lung Cancer Mesothelioma Breast Cancer Ovarian Cancer 收起 << Phase 1 Active, not recruiting October 2020 United States, Pennsylvania ... 展开 >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 收起 <<

Valacyclovir hydrochloride 参考文献

[1]MacDougall C, Guglielmo BJ. Pharmacokinetics of valaciclovir. J Antimicrob Chemother. 2004 Jun;53(6):899-901.

[2]Patel R. Valaciclovir: development, clinical utility and potential. Expert Opin Investig Drugs. 1997 Feb;6(2):173-89.

[3]Biernat-Sudolska M. Valaciclovir [Valacyclovir]. Przegl Lek. 1998;55(11):596-8. Polish

[4]Wu JJ, Brentjens MH, Torres G, Yeung-Yue K, Lee P, Tyring SK. Valacyclovir in the treatment of herpes simplex, herpes zoster, and other viral infections. J Cutan Med Surg. 2003 Sep-Oct;7(5):372-81

[5]Brantley JS, Hicks L, Sra K, Tyring SK. Valacyclovir for the treatment of genital herpes. Expert Rev Anti Infect Ther. 2006 Jun;4(3):367-76

[6]Corey L, Wald A, Patel R, Sacks SL, Tyring SK, Warren T, Douglas JM Jr, Paavonen J, Morrow RA, Beutner KR, Stratchounsky LS, Mertz G, Keene ON, Watson HA, Tait D, Vargas-Cortes M; Valacyclovir HSV Transmission Study Group. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med. 2004 Jan 1;350(1):11-20

Valacyclovir hydrochloride 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.86mL

2.77mL

1.39mL

27.72mL

5.54mL

2.77mL

Valacyclovir hydrochloride 技术信息

CAS号124832-27-5
分子式C13H21ClN6O4
分子量 360.797
别名 盐酸伐昔洛韦 ;Valaciclovir hydrochloride;L-Valacyclovir (hydrochloride);BW 256U87;BW 256U;Valaciclovir HCl
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 45 mg/mL(124.72 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(277.16 mM),配合低频超声助溶

动物实验配方

PO 0.5% CMC-Na 50 mg/mL suspension

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