URB937 is a FAAH inhibitor and increases anandamide levels, with an IC50 of 26.8 nM. URB937 fails to affect FAAH activity in the brain .
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产品名称 | FAAH ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
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URB-597 |
++++
FAAH, IC50: 4.6 nM |
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JNJ-1661010 |
+++
FAAH (rat), IC50: 10 nM FAAH (human), IC50: 12 nM |
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Biochanin A |
+
FAAH (mouse), IC50: 1.8 μM FAAH (human), IC50: 1.4 μM |
EGFR | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
PF-3845 |
++
FAAH, Ki: 230 nM |
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | URB937 is a peripherally restricted FAAH inhibitor with oral activity and an IC50 value of 26.8 nM. URB937 does not affect FAAH activity in the brain (does not penetrate the blood-brain barrier)[1].URB937 is actively excreted from the CNS by the ATP-binding cassette (ABC) membrane transporter Abcg2[2]. |
Animal study | Administered intraperitoneally at a dose of 1 mg/kg, URB937 increases anandamide levels in peripheral tissues of mice, but not in the forebrain or hypothalamus. Administered subcutaneously at a dose of 1 mg/kg, URB937 inhibited the pain response induced by intraperitoneal injection of acetic acid[1].URB937 produced highly antinociceptive effects in visceral pain and inflammatory pain models in female mice and rats. In addition, URB937 displays restricted access to placental and fetal tissues in pregnant mice and rats[2].At a dose of 1 mg/kg administered every two days for 30 days, URB937 attenuated radiation-induced lung injury and increased endogenous cannabinoid concentrations in lung tissue[3]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.82mL 0.56mL 0.28mL |
14.11mL 2.82mL 1.41mL |
28.22mL 5.64mL 2.82mL |
CAS号 | 1357160-72-5 |
分子式 | C20H22N2O4 |
分子量 | 354.4 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 250 mg/mL(705.42 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |