UAMC00039 2HCl
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货号：A709631
同义名：
UAMC 0039 (hydrochloride);UAMC00039 dihydrochloride
UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.
UAMC00039 2HCl 化学结构
UAMC00039 2HCl 3D分子结构
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UAMC00039 2HCl 纯度/质量文件 产品仅供科研
货号：A709631
标准纯度：
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UAMC00039 2HCl 质控信息
UAMC00039 2HCl 生物活性
描述
Dipeptidyl peptidase II (DPPII) is an intracellular protease that localizes to the vesicular system. It releases, preferably at acidic pH, N-terminal dipeptides from oligopeptides with Pro or Ala in the penultimate position. UAMC00039 is a potent reversible competitive tight binding DPPII inhibitor with a Ki of 0.082 nM and an IC50 of 0.48 nM. Both 1 and 100 μM of UAMC00039 inhibited DPPII activity of PBMC and U937 cells more than 90%. UAMC00039 concentrations up to 100 μM were non-toxic for U937 cells for at least 48 h[3] [4]
UAMC00039 2HCl 参考文献
[1] Maes MB, et al. In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII. Adv Exp Med Biol. 2006;575:73-85.
[2] Maes MB, et al. Dipeptidyl peptidase II and leukocyte cell death. Biochem Pharmacol. 2006 Jun 28;72(1):70-9.
[3] Maes MB, Martinet W, Schrijvers DM, et al. Dipeptidyl peptidase II and leukocyte cell death. Biochem Pharmacol . 2006;72(1):70-79
[4] Maes MB, Lambeir AM, Van der Veken P, et al. In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII. Adv Exp Med Biol . 2006;575:73-85
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UAMC00039 2HCl 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.61mL
0.52mL
0.26mL
13.06mL
2.61mL
1.31mL
26.13mL
5.23mL
2.61mL
UAMC00039 2HCl 技术信息
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