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UAMC00039 2HCl

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Chemical Structure| 697797-51-6 同义名 : UAMC 0039 (hydrochloride);UAMC00039 dihydrochloride;UAMC00039, UAMC 00039, UAMC-00039, UAMC 00039 dihydrochloride, UAMC 00039 2HCl
CAS号 : 697797-51-6
货号 : A709631
分子式 : C16H26Cl3N3O
纯度 : 99%+
分子量 : 382.756
MDL号 : MFCD27937768
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(378.83 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(261.26 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Dipeptidyl peptidase II (DPPII) is an intracellular protease that localizes to the vesicular system. It releases, preferably at acidic pH, N-terminal dipeptides from oligopeptides with Pro or Ala in the penultimate position. UAMC00039 is a potent reversible competitive tight binding DPPII inhibitor with a Ki of 0.082 nM and an IC50 of 0.48 nM. Both 1 and 100 μM of UAMC00039 inhibited DPPII activity of PBMC and U937 cells more than 90%. UAMC00039 concentrations up to 100 μM were non-toxic for U937 cells for at least 48 h[3]. A dose dependent inhibition of DPPII was observed in the peripheral organs of both the rats and the mice (after oral administration) and the rabbits (after IV administration)[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.06mL

2.61mL

1.31mL

26.13mL

5.23mL

2.61mL
参考文献

[1]Maes MB, et al. In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII. Adv Exp Med Biol. 2006;575:73-85.

[2]Maes MB, et al. Dipeptidyl peptidase II and leukocyte cell death. Biochem Pharmacol. 2006 Jun 28;72(1):70-9.

[3]Maes MB, Martinet W, Schrijvers DM, et al. Dipeptidyl peptidase II and leukocyte cell death. Biochem Pharmacol. 2006;72(1):70-79

[4]Maes MB, Lambeir AM, Van der Veken P, et al. In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII. Adv Exp Med Biol. 2006;575:73-85