Trimebutine maleate is an orally administered anti-tumor agent. It has the ability to selectively inhibit the stemness and proliferation of ovarian cancer stem cells (CSCs). Additionally, Trimebutine maleate alleviates colonic muscle hypercontractility, regulates gastrointestinal motility, and promotes apoptosis, making it a valuable candidate for research in glioma/glioblastoma and irritable bowel syndrome[1].[2].[3].[4].[5].[6].
体内研究
Furthermore, when administered orally at doses of 25-50 mg/kg in a single dose, Trimebutine maleate lessens the response to colorectal distension in C57Bl6 male mice, indicating its potential effectiveness in addressing gastrointestinal discomfort[4].
体外研究
In vitro, Trimebutine maleate (1-20 μM, 60 h) has been shown to reduce the growth of A2780-SP cells dose-dependently[2].
Trimebutine maleate (1-10 μM, 24 h) also diminishes stem cell characteristics of A2780-SP cells by concurrently inhibiting calcium and BKCa channels[2].
For glioma and glioblastoma cells, Trimebutine maleate (10-200 μM, 24-72 h) not only reduces cell viability and migration but also obstructs the ERK and AKT signaling pathways, which are critical for cell proliferation and survival[3].
Korea, Republic of
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Korea University Ansan Hospital
Ansan, Korea, Republic of
Hallym University Sacred Heart Hospital
Anyang, Korea, Republic of
Kangwon National University Hospital
Chuncheon, Korea, Republic of
Gachon University Gil Hospital
Incheon, Korea, Republic of
Inje University Seoul Paik Hospital
Seoul, Korea, Republic of
Korea University Anam Hospital
Seoul, Korea, Republic of
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Chungmu General Hopsital
Recruiting
Seoul, Yeongdeungpo-gu, Korea, Republic of, 150-034
Contact: Sang Hoon Lhee, MD, Phd +82 (2) 2068/4525 cmirb@naver.com
Principal Investigator: Paolo Alan B Tabar, MD 收起 <<
Korea, Republic of
... 展开 >>
Korea University Ansan Hospital
Ansan, Korea, Republic of
Hallym University Sacred Heart Hospital
Anyang, Korea, Republic of
Kangwon National University Hospital
Chuncheon, Korea, Republic of
Gachon University Gil Hospital
Incheon, Korea, Republic of
Inje University Seoul Paik Hospital
Seoul, Korea, Republic of
Korea University Anam Hospital
Seoul, Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of 收起 <<
Korea, Republic of
... 展开 >>
Chungmu General Hopsital
Recruiting
Seoul, Yeongdeungpo-gu, Korea, Republic of, 150-034
Contact: Sang Hoon Lhee, MD, Phd +82 (2) 2068/4525 cmirb@naver.com
Principal Investigator: Paolo Alan B Tabar, MD 收起 <<
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