货号:A244345 同义名: 3,3',5-Triiodothyroacetic acid;3,3′,5-Triiodothyroacetic acid
Tiratricol是一种甲状腺激素类似物,具有肝脏作用,已用于抑制垂体 TSH 分泌,并减轻外垂体的类甲状腺激素效应。Tiratricol 还是一种细胞内毒素中和剂,可以抑制 LPS 和 lipid A 的细胞毒性,IC50s 分别为 20 μM 和 32μM。
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描述 | Thyroid hormone receptor is a type of nuclear receptor which control transcription and have effects in all cells within the body. Tiratricol is an agonist of the thyroid hormone receptor TRα and TRβ (EC50= 1.81 and 4.13nM, respectively)[3]. In vivo, tiratricol (50 or 400 ng/g) stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in Mct8/Oatp1c1 double knockout mice[4]. It reduces goiter induced by methimazole in rats when administered at a dose of 25 μg per animal[5]. Tiratricol also decreases toll-like receptor 2 (TLR2) levels and the phosphorylation of Akt and MAPK in HEK-Blue™ cells expressing human TLR2 and reduces liver tissue necrosis in a mouse model of hepatitis induced by concanavalin A[6]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.61mL 0.32mL 0.16mL |
8.04mL 1.61mL 0.80mL |
16.08mL 3.22mL 1.61mL |
CAS号 | 51-24-1 |
分子式 | C14H9I3O4 |
分子量 | 621.932 |
别名 | 3,3',5-Triiodothyroacetic acid;3,3′,5-Triiodothyroacetic acid;TRIAC;triiodothyroacetic acid |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place,Inert atmosphere,Room temperature |
溶解方案 |
DMSO: 40 mg/mL(64.32 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |