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Tiratricol

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Chemical Structure| 51-24-1 同义名 : 3,3',5-Triiodothyroacetic acid;3,3′,5-Triiodothyroacetic acid;TRIAC;triiodothyroacetic acid
CAS号 : 51-24-1
货号 : A244345
分子式 : C14H9I3O4
纯度 : 98%
分子量 : 621.932
MDL号 : MFCD00055931
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(64.32 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Thyroid hormone receptor is a type of nuclear receptor which control transcription and have effects in all cells within the body. Tiratricol is an agonist of the thyroid hormone receptor TRα and TRβ (EC50= 1.81 and 4.13nM, respectively)[3]. In vivo, tiratricol (50 or 400 ng/g) stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in Mct8/Oatp1c1 double knockout mice[4]. It reduces goiter induced by methimazole in rats when administered at a dose of 25 μg per animal[5]. Tiratricol also decreases toll-like receptor 2 (TLR2) levels and the phosphorylation of Akt and MAPK in HEK-Blue™ cells expressing human TLR2 and reduces liver tissue necrosis in a mouse model of hepatitis induced by concanavalin A[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.61mL

0.32mL

0.16mL

8.04mL

1.61mL

0.80mL

16.08mL

3.22mL

1.61mL
参考文献

[1]Carvalho GA, Ramos HE. [Thyroid hormone resistance syndrome] . Arq Bras Endocrinol Metabol. 2004 Feb;48(1):83-92. Epub 2004 Jun 1.

[2]Brenta G, Schnitman M, et al. Comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid. J Clin Endocrinol Metab. 2003 Nov;88(11):5287-92.

[3]Oka T, Mitsui-Watanabe N, Tatarazako N, et al. Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors. J Appl Toxicol. 2013;33(9):991-1000.

[4]Kersseboom S, Horn S, Visser WE, et al. In vitro and mouse studies supporting therapeutic utility of triiodothyroacetic acid in MCT8 deficiency. Mol Endocrinol. 2014;28(12):1961-1970.

[5]Alvarez L, Burgueño A, Zeni S, et al. Comparison of the effects of 3,5,3'-triiodothyroacetic Acid and triiodothyronine on goiter prevention and involution and on hepatic and skeletal parameters in rats. Horm Metab Res. 2004;36(5):291-297.

[6]Ha HC, Jang JM, Zhou D, et al. 3, 5, 3'-Triiodothyroacetic acid (TRIAC) is an anti-inflammatory drug that targets toll-like receptor 2. Arch Pharm Res. 2018;41(10):995-1008.