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噻氯匹啶 /Ticlopidine {[allProObj[0].p_purity_real_show]}

货号:A269629 同义名: PCR 5332

Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.

Ticlopidine 化学结构 CAS号:55142-85-3
Ticlopidine 化学结构
CAS号:55142-85-3
Ticlopidine 3D分子结构
CAS号:55142-85-3
Ticlopidine 化学结构 CAS号:55142-85-3
Ticlopidine 3D分子结构 CAS号:55142-85-3
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Ticlopidine 纯度/质量文件 产品仅供科研

货号:A269629 标准纯度: {[allProObj[0].p_purity_real_show]}
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Ticlopidine 生物活性

描述 Ticlopidine is a selective and the first FDA-approved P2Y12 antagonist which can affect platelet aggregation when. It can be metabolized through cytochrome P450 in the liver and forms the active thienopyridine metabolites. The thienopyridine metabolites can irreversibly antagonize the P2Y12 receptor[3]. This results in inhibition of the binding of the P2Y12 agonist 2-methylthio-ADP and the ADP-induced downregulation of adenylyl cyclase[4].

Ticlopidine 动物研究

Dose Rat: 4 mg/kg, 10 mg/kg[3] (p.o.), 10 mg/kg - 300 mg/kg[4] (p.o.); 125 mg/kg[5] (i.p.); 25 mg/kg[6] (i.v.)
Administration p.o., i.p., i.v.

Ticlopidine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00889044 Platlet Aggregation ... 展开 >> Major Bleeding Outcomes 收起 << Phase 3 Unknown June 2011 Israel ... 展开 >> Sheba_medical_center Not yet recruiting Ramat-Gan, Israel Contact: Shlomo Matetzky, M.D    972-3-5302504    Shlomi.Matetzky@sheba.health.gov.il    Sub-Investigator: Elad Asher, M.D          Sheba Medical Center, Cardiac Institute Recruiting Tel Hashomer, Israel Contact: Shlomi Matetzky, MD    972-3-530-2504    shlomi.matetzky@sheba.health.gov.il    Contact: Elad Asher, MD    972-3-530-2504    elad.asher@sheba.health.gov.il 收起 <<
NCT00853450 Antiplatelet Effect Phase 1 Completed - Sweden ... 展开 >> Research Site Lund, Sweden 收起 <<
NCT00944333 Angina Pectoris ... 展开 >> Silent Ischemia 收起 << Phase 3 Terminated(STOP due to recent ... 展开 >>data in literature questioning the need to continue DAP beyond six months in patients with stable coronary artery stenting with DES.) 收起 << - Italy ... 展开 >> Irccs Fondazione Centro S. Raffaele Del Monte Tabor - Milano (mi), Italy, 20132 收起 <<

Ticlopidine 参考文献

[1]Michelson AD, et al. P2Y12 antagonism: promises and challenges. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):s33-8.

[2]Savi P, Herbert JM, et al. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin Thromb Hemost. 2005 Apr;31(2):174-83.

[3]Michelson AD. P2Y12 antagonism: promises and challenges. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):s33-8. doi: 10.1161/ATVBAHA.107.160689. Epub 2008 Jan 3. PMID:18174449.

[4]Savi P, Herbert JM. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin Thromb Hemost. 2005 Apr;31(2):174-83. doi: 10.1055/s-2005-869523. PMID: 15852221.

Ticlopidine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.79mL

0.76mL

0.38mL

18.95mL

3.79mL

1.90mL

37.91mL

7.58mL

3.79mL

Ticlopidine 技术信息

CAS号55142-85-3
分子式C14H14ClNS
分子量 263.786
别名 PCR 5332
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(398.05 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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