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盐酸噻氯匹定 /Ticlopidine HCl {[allProObj[0].p_purity_real_show]}

货号:A218498 同义名: 噻氯匹定盐酸盐 / Ticlopidine (hydrochloride);Ticlopidine hydrochloride

Ticlopidine HCl is an adenosine diphosphate (ADP) receptor inhibitor that against platelet aggregation with IC50 of ~2 μM.

Ticlopidine HCl 化学结构 CAS号:53885-35-1
Ticlopidine HCl 化学结构
CAS号:53885-35-1
Ticlopidine HCl 3D分子结构
CAS号:53885-35-1
Ticlopidine HCl 化学结构 CAS号:53885-35-1
Ticlopidine HCl 3D分子结构 CAS号:53885-35-1
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Ticlopidine HCl 纯度/质量文件 产品仅供科研

货号:A218498 标准纯度: {[allProObj[0].p_purity_real_show]}
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Ticlopidine HCl 生物活性

靶点
  • P2 receptor

    P2 receptor, IC50:~2 μM

描述 Ticlopidine Hydrochloride is a hydrochloride form of Ticlopidine. Ticlopidine is a selective and the first FDA-approved P2Y12 antagonist which can affect platelet aggregation when. It can be metabolized through cytochrome P450 in the liver and forms the active thienopyridine metabolites. The thienopyridine metabolites can irreversibly antagonize the P2Y12 receptor[3]. This results in inhibition of the binding of the P2Y12 agonist 2-methylthio-ADP and the ADP-induced downregulation of adenylyl cyclase[4].

Ticlopidine HCl 动物研究

Dose Rat: 10 mg/kg - 300 mg/kg[3] (p.o.) Mice: 10 mg/kg[4] (i.p.)
Administration p.o., i.p.

Ticlopidine HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01381185 Acute Myocardial Infarction Phase 4 Completed - Czech Republic ... 展开 >> University Hospital Ostrava Ostrava, Poruba, Czech Republic, 70852 Departement of Laboratory Medicine, Prostejov Hospital Prostejov, Czech Republic, 79604 收起 <<
NCT01448330 Healthy Phase 1 Completed - Korea, Republic of ... 展开 >> Samsung medical center Seoul, Korea, Republic of 收起 <<
NCT01469416 Healthy Phase 1 Completed - United States, California ... 展开 >> Clinical Research Center, UCSF San Francisco, California, United States, 94143 收起 <<

Ticlopidine HCl 参考文献

[1]Michelson AD, et al. P2Y12 antagonism: promises and challenges. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):s33-8.

[2]Savi P, Herbert JM, et al. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin Thromb Hemost. 2005 Apr;31(2):174-83.

[3]Michelson AD. P2Y12 antagonism: promises and challenges. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):s33-8. doi: 10.1161/ATVBAHA.107.160689. Epub 2008 Jan 3. PMID:18174449.

[4]Savi P, Herbert JM. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin Thromb Hemost. 2005 Apr;31(2):174-83. doi: 10.1055/s-2005-869523. PMID: 15852221.

Ticlopidine HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.65mL

3.33mL

1.67mL

33.31mL

6.66mL

3.33mL

Ticlopidine HCl 技术信息

CAS号53885-35-1
分子式C14H15Cl2NS
分子量 300.247
别名 噻氯匹定盐酸盐 ;Ticlopidine (hydrochloride);Ticlopidine hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 50 mg/mL(166.53 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(166.53 mM),配合低频超声助溶

动物实验配方

PO 0.5% CMC-Na 80 mg/mL suspension

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