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盐酸替莫普利 /Temocapril HCl {[allProObj[0].p_purity_real_show]}

货号:A151541 同义名: Temocapril (hydrochloride);CS-622 HCl

Temocapril HCl is a long-acting and prodrug-type ACE inhibitor,not approved for use in US, but approved in Japan and South Korea.

Temocapril HCl 化学结构 CAS号:110221-44-8
Temocapril HCl 化学结构
CAS号:110221-44-8
Temocapril HCl 3D分子结构
CAS号:110221-44-8
Temocapril HCl 化学结构 CAS号:110221-44-8
Temocapril HCl 3D分子结构 CAS号:110221-44-8
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Temocapril HCl 纯度/质量文件 产品仅供科研

货号:A151541 标准纯度: {[allProObj[0].p_purity_real_show]}
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Temocapril HCl 生物活性

描述 Temocapril hydrochloride is a novel prodrug-type angiotensin-I converting enzyme (ACE) inhibitor, lowering of the dose of temocapril might be recommended only in patients with severe renal insufficiency[3]. Temocapril hydrochloride decreases tumor tBF (tissue blood flow) markedly in LY80 tumor, a subline of Yoshida sarcoma in the rat, without affecting the blood flow in liver, kidney, bone marrow, and brain[4].

Temocapril HCl 参考文献

[1]Miyashita Y, Ito Y, et al. Effect of temocapril hydrochloride on serum lipid levels in patients with hypertensive type 2 diabetes mellitus. J Atheroscler Thromb. 2001;8(1):25-9.

[2]Nakashima M, Yamamoto J, et al. Pharmacokinetics of temocapril hydrochloride, a novel angiotensin converting enzyme inhibitor, in renal insufficiency. Eur J Clin Pharmacol. 1992;43(6):657-9.

[3]Nakashima M, Yamamoto J, Shibata M, Uematsu T, Shinjo H, Akahori T, Shioya H, Sugiyama K, Kawahara Y. Pharmacokinetics of temocapril hydrochloride, a novel angiotensin converting enzyme inhibitor, in renal insufficiency. Eur J Clin Pharmacol. 1992;43(6):657-9. doi: 10.1007/BF02284968. PMID: 1493850.

[4]Hori K, Saito S, Takahashi H, Sato H, Maeda H, Sato Y. Tumor-selective blood flow decrease induced by an angiotensin converting enzyme inhibitor, temocapril hydrochloride. Jpn J Cancer Res. 2000 Feb;91(2):261-9. doi: 10.1111/j.1349-7006.2000.tb00940.x. PMID: 10761715; PMCID: PMC5926331.

Temocapril HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.19mL

9.75mL

1.95mL

0.97mL

19.49mL

3.90mL

1.95mL

Temocapril HCl 技术信息

CAS号110221-44-8
分子式C23H29ClN2O5S2
分子量 513.07
别名 Temocapril (hydrochloride);CS-622 HCl;CS 622;Temocapril hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 60 mg/mL(116.94 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 2 mg/mL(3.9 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 6 mg/mL clear

PO 0.5% CMC-Na 20 mg/mL suspension

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