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Temocapril HCl

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Chemical Structure| 110221-44-8 同义名 : Temocapril (hydrochloride);CS-622 HCl;CS 622;Temocapril hydrochloride
CAS号 : 110221-44-8
货号 : A151541
分子式 : C23H29ClN2O5S2
纯度 : 99%+
分子量 : 513.07
MDL号 : MFCD00933433
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(116.94 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(3.9 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：

IP 2% DMSO+2% Tween80+40% PEG300+water 6 mg/mL clear

PO 0.5% CMC-Na 20 mg/mL suspension

生物活性
描述 Temocapril hydrochloride is a novel prodrug-type angiotensin-I converting enzyme (ACE) inhibitor, lowering of the dose of temocapril might be recommended only in patients with severe renal insufficiency[3]. Temocapril hydrochloride decreases tumor tBF (tissue blood flow) markedly in LY80 tumor, a subline of Yoshida sarcoma in the rat, without affecting the blood flow in liver, kidney, bone marrow, and brain[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.19mL

9.75mL

1.95mL

0.97mL

19.49mL

3.90mL

1.95mL
参考文献

[1]Miyashita Y, Ito Y, et al. Effect of temocapril hydrochloride on serum lipid levels in patients with hypertensive type 2 diabetes mellitus. J Atheroscler Thromb. 2001;8(1):25-9.

[2]Nakashima M, Yamamoto J, et al. Pharmacokinetics of temocapril hydrochloride, a novel angiotensin converting enzyme inhibitor, in renal insufficiency. Eur J Clin Pharmacol. 1992;43(6):657-9.

[3]Nakashima M, Yamamoto J, Shibata M, Uematsu T, Shinjo H, Akahori T, Shioya H, Sugiyama K, Kawahara Y. Pharmacokinetics of temocapril hydrochloride, a novel angiotensin converting enzyme inhibitor, in renal insufficiency. Eur J Clin Pharmacol. 1992;43(6):657-9. doi: 10.1007/BF02284968. PMID: 1493850.

[4]Hori K, Saito S, Takahashi H, Sato H, Maeda H, Sato Y. Tumor-selective blood flow decrease induced by an angiotensin converting enzyme inhibitor, temocapril hydrochloride. Jpn J Cancer Res. 2000 Feb;91(2):261-9. doi: 10.1111/j.1349-7006.2000.tb00940.x. PMID: 10761715; PMCID: PMC5926331.