Tasimelteon | BMS-214778 | Dual Melatonin Receptor Agonist

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他司美琼 /Tasimelteon {[allProObj[0].p_purity_real_show]}

货号：A125322 同义名： BMS-214778;VEC-162

Tasimelteon is a melatonin MT1 and MT2 receptor agonist.

Tasimelteon 化学结构
CAS号：609799-22-6

Tasimelteon 3D分子结构
CAS号：609799-22-6

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Tasimelteon 纯度/质量文件产品仅供科研

货号：A125322 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Tasimelteon 生物活性

描述	Tasimelteon (BMS-214778) is a dual melatonin receptor agonist (DMRA) with 2.1-4.4 times greater affinity for the MT2 receptor than the MT1 receptor, making it a potential circadian regulator for Non-24-Hour Sleep-Wake Disorder (Non-24) ^[1]^[2].
体外研究	Tasimelteon (BMS-214778) exhibits significantly higher affinity for the MT2 receptor (Ki=0.0692 nM and Ki=0.17 nM in NIH-3T3 and CHO-K1 cells, respectively) compared to the MT1 receptor (Ki=0.304 nM and Ki=0.35 nM, respectively). It lacks appreciable affinity for over 160 other pharmacologically relevant receptors and several enzymes ^[1].

Tasimelteon 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00548340	Primary Insomnia	Phase 3	Completed	-	-
NCT00548340	-		Completed	-	-
NCT01402076	Healthy Volunteers	Phase 1	Completed	-	United States, Missouri ... 展开 >> Bio-Kinetic Clinical Applications Springfield, Missouri, United States, 65802 收起 <<

Tasimelteon 参考文献

[1]Christian Lavedan, et al. Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology. 2015 Apr;91:142-7.

[2]Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.

Tasimelteon 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.08mL

0.82mL

0.41mL

20.38mL

4.08mL

2.04mL

40.76mL

8.15mL

4.08mL

Tasimelteon 技术信息

CAS号	609799-22-6
分子式	C₁₅H₁₉NO₂
分子量	245.317

别名	BMS-214778;VEC-162;BMS214778, BMS-214778, BMS 214778, VEC162, VEC-162, VEC 162, Tasimelteon, Hetlioz;BMS 214778
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 35 mg/mL(142.67 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00548340	Primary Insomnia	Phase 3	Completed	-	-
NCT00548340	-		Completed	-	-
NCT01402076	Healthy Volunteers	Phase 1	Completed	-	United States, Missouri ... 展开 >> Bio-Kinetic Clinical Applications Springfield, Missouri, United States, 65802 收起 <<
NCT02231008	Smith-Magenis Syndrome ... 展开 >> Circadian 收起 <<	Phase 2 Phase 3	Unknown	-	United States, California ... 展开 >> Santa Monica Clinical Trials Recruiting Santa Monica, California, United States, 90404 Contact: Kerri kcali@smclinicaltrials.com United States, Maryland The Center for Sleep & Wake Disorders Recruiting Chevy Chase, Maryland, United States, 20815 Contact: Jaime sleepdoc@sleepdoc.com United States, Texas Baylor Clinic Recruiting Houston, Texas, United States, 77030 Contact: Zohra Zohra.Huda@bcm.edu 收起 <<
NCT01430754	-		Completed	-	-
NCT01430754	Non-24-Hour Sleep-Wake Disorde... 展开 >>r 收起 <<	Phase 3	Completed	-	-
NCT01428661	-		Completed	-	-
NCT03373201	Jet Lag Type Insomnia	Phase 3	Completed	-	United States, Arkansas ... 展开 >> Vanda Investigational Site Little Rock, Arkansas, United States, 72211 United States, California Vanda Investigational Site Alameda, California, United States, 94501 Vanda Investigational Site San Diego, California, United States, 92103 Vanda Investigational Site Santa Monica, California, United States, 90404 United States, Florida Vanda Investigational Site Oakland Park, Florida, United States, 33334 United States, Georgia Vanda Investigational Site Atlanta, Georgia, United States, 30342 United States, Maryland Vanda Investigational Site Chevy Chase, Maryland, United States, 20815 United States, Missouri Vanda Investigational Site Saint Louis, Missouri, United States, 63141 United States, New York Vanda Investigational Site New York, New York, United States, 10019 United States, Ohio Vanda Investigational Site Cincinnati, Ohio, United States, 45212 United States, Oklahoma Vanda Investigational Site Oklahoma City, Oklahoma, United States, 73112 United States, Texas Vanda Investigational Site Houston, Texas, United States, 77063 收起 <<
NCT01526746	Renal Impairment	Phase 1	Completed	-	United States, Florida ... 展开 >> Clinical Pharmacology of Miami, Inc. Miami, Florida, United States, 33014 Orlando Clinical Research Center Orlando, Florida, United States, 32809 United States, Minnesota DaVita Clinical Research Minneapolis, Minnesota, United States 收起 <<
NCT01637636	Healthy	Phase 1	Completed	-	United States, Missouri ... 展开 >> QPS Bio-Kinetic Clinical Applications Springfield, Missouri, United States, 65802 收起 <<
NCT03291041	Jet Lag Disorder	Phase 2	Completed	-	United States, California ... 展开 >> Vanda Investigational Site Alameda, California, United States, 94501 Vanda Investigational Site Santa Monica, California, United States, 90404 United States, Maryland Vanda Investigational Site Chevy Chase, Maryland, United States, 20815 收起 <<
NCT01428661	Major Depressive Disorder	Phase 2 Phase 3	Completed	-	-
NCT01163032	-		Completed	-	-
NCT01540500	Healthy Volunteers	Phase 1	Completed	-	United States, Missouri ... 展开 >> Bio-Kinetic Clinical Applications Springfield, Missouri, United States, 65802 收起 <<
NCT01477619	Healthy Volunteers	Phase 1	Completed	-	United States, Missouri ... 展开 >> Bio-Kinetic Clinical Applications Springfield, Missouri, United States 收起 <<
NCT01578057	Pharmacodyamics and Pharmacoki... 展开 >>netics of Tasimelteon Alone and in Combination With Ethanol 收起 <<	Phase 1	Completed	-	Canada, Ontario ... 展开 >> INC Research Toronto, Inc. Toronto, Ontario, Canada, M5V 2TC 收起 <<
NCT01429116	Non-24-Hour Sleep-Wake Disorde... 展开 >>r 收起 <<	Phase 3	Completed	-	-
NCT01218789	Non 24 Hour Sleep Wake Disorde... 展开 >>r 收起 <<	Phase 3	Recruiting	December 2018	France ... 展开 >> Recruiting Garches, France Recruiting Lille, France Recruiting Lyon, France Recruiting Montpellier, France Recruiting Paris, France Recruiting Rennes, France Recruiting Toulouse, France 收起 <<
NCT02776215	Circadian Rhythm Sleep Disorde... 展开 >>rs Non-24 Hour Sleep-Wake Disorder Autism Spectrum Disorder Smith-Magenis Syndrome 收起 <<	Phase 1	Recruiting	-	United States, Maryland ... 展开 >> Parexel Early Phase Clinical Unit Recruiting Baltimore, Maryland, United States, 21225 Contact: Amy Roach 667-210-5356 Amy.Roach@parexel.com Principal Investigator: Shannon Marriot 收起 <<
NCT01163032	Non-24-Hour Sleep-Wake Disorde... 展开 >>r 收起 <<	Phase 3	Completed	-	-
NCT01271387	Hepatic Impairment	Phase 1	Completed	-	United States, Florida ... 展开 >> Orlando Clinical Research Center Orlando, Florida, United States, 32809 收起 <<
NCT02130999	-		Completed	-	-
NCT02130999	Non-24-Hour-Sleep-Wake Disorde... 展开 >>r 收起 <<	Phase 4	Completed	-	-

他司美琼 /Tasimelteon {[allProObj[0].p_purity_real_show]}

Tasimelteon 纯度/质量文件产品仅供科研

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他司美琼 /Tasimelteon {[allProObj[0].p_purity_real_show]}

Tasimelteon 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Tasimelteon 质控信息

Tasimelteon 生物活性

Tasimelteon 临床研究

Tasimelteon 参考文献

Tasimelteon 实验方案

Tasimelteon 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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