生物活性 | |||
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描述 | Tasimelteon (BMS-214778) is a dual melatonin receptor agonist (DMRA) with 2.1-4.4 times greater affinity for the MT2 receptor than the MT1 receptor, making it a potential circadian regulator for Non-24-Hour Sleep-Wake Disorder (Non-24) [1][2]. |
临床研究 | |||||
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00548340 | Primary Insomnia | Phase 3 | Completed | - | - |
NCT00548340 | - | Completed | - | - | |
NCT01402076 | Healthy Volunteers | Phase 1 | Completed | - | United States, Missouri ... 展开 >> Bio-Kinetic Clinical Applications Springfield, Missouri, United States, 65802 收起 << |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.08mL 0.82mL 0.41mL |
20.38mL 4.08mL 2.04mL |
40.76mL 8.15mL 4.08mL |
参考文献 |
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