TTPU is an inhibitor of epoxide hydrolase (sEH) with IC50 of 3.7 nM with anti-inflammatory and anti-atherosclerotic activities.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
The soluble epoxide hydrolase (sEH) converts epoxides to diols by catalytic addition of a water molecule. It has been shown to metabolize fatty acid epoxides in various human diseases. TPPU is a potent sEH inhibitor with IC50 values of 3.7 and 2.8nM for human and murine sHE, respectively[1]. TPPU also shows inhibitory activity against monkey sEH with an IC50 value of 37nM[2]. TPPU binds to recombinant human sEH with a Ki value of 0.9±0.1nM and koff of 10.5×10-4/s. Administration of rats with 10mg/kg TPPU via oral gavage inhibited human sEH with an IC50 value of 1.1±0.1nM[3].
搜索
HazMat Fee +
