T0901317 | LXR Agonist | AmBeed-信号通路专用抑制剂

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T0901317 99%

货号：A467377

T0901317是一种LXR和FXR选择性激动剂，EC50分别为50 nM和5 μM。

T0901317 化学结构
CAS号：293754-55-9

T0901317 3D分子结构
CAS号：293754-55-9

规格	价格	库存	数量
100μL*10mM(DMSO)	￥109随货￥79	现货	- +
250μL*10mM(DMSO)	￥229随货￥169	现货	- +
500μL*10mM(DMSO)	￥299随货￥209	现货	- +
10mM*1mL(DMSO)	￥462	现货	- +
5mg	￥237	现货	- +
10mg	￥378	现货	- +
25mg	￥630	现货	- +
50mg	￥756	现货	- +
100mg	￥1229	现货	- +
1g	￥12285	咨询

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T0901317 纯度/质量文件产品仅供科研

货号：A467377 标准纯度： 99% 产品说明书

批次查询：批次纯度: COA NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • ACS Appl. Nano Mater., 2025. Ambeed. [ A188026 ]; • Eur. J. Clin. Microbiol. Infect. Dis., 2025. Ambeed. [ A151161 ]; • JJC, 2025, 20(Special Issue)): 27-39. Ambeed. [ A713856 ]; • bioRxiv, 2025. Ambeed. [ A538667 , A714873 , A126729 , A126049 , A446054 ]; • Nature Communications, 2025, 16, 1871. Ambeed. [ A508148 ]; 更多 >

T0901317 生物活性

描述

T0901317 is a dual LXR/FXR agonist (more potent to LXR than FXR) and an inverse agonist of CAR. T0901317 at concentration ranging in 1-10μM induced FXR target genes BSEP and SHP mRNA expression in a dose-dependent manner in Huh7 cells. The transcription activity of GAL4-hCAR/LBD was repressed by T0901317 with IC50 value of 2.2μM, while the transcription activity of GAL4-LXR/LBD was increased by T0901317 with EC50 value of 0.21μM. A significant repression of Tet-induced CAR:RXR-mediated luciferase activity could also be observed after treatment with 10μM T0901317. Treatment with 10μM T0901317 for 48h reduced hCAR-mediated CYP2B6 expression on mRNA level in HepTR-hCAR cells.

T0901317 细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
CHO cells		Function assay		Agonist activity at human LXR beta receptor expressed in CHO cells by reporter assay, EC50=16 nM	19853462
COS7 cells		Function assay	16 h	Agonist activity at human LXRbeta receptor transfected in COS7 cells after 16 hrs by reporter transactivation assay, EC50=11 nM	17587573
CV1 cells		Function assay		Transactivation of LXRbeta (unknown origin) expressed in CV1 cells by luciferase reporter gene assay, EC50=0.14 μM	25435151
HEK293 cells		Function assay		Agonist activity at human LXRbeta in HEK293 cells assessed as Gal4 transactivation, EC50=19 nM	20350005

T0901317 动物研究

Dose	Cynomolgus monkey: 10 mg/kg^[4] (p.o.) Rat: 10 mg/kg^[5] (p.o.) BALB/c mice: 10 mg/kg - 100 mg/kg^[6] (p.o.)
Administration	p.o.

T0901317 参考文献

[1]Repa JJ, Turley SD, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 2000 Sep 1;289(5484):1524-9.

[2]Houck KA, Borchert KM, et al. T0901317 is a dual LXR/FXR agonist. Mol Genet Metab. 2004 Sep-Oct;83(1-2):184-7.

[3]Kanno Y, Tanuma N, et al. TO901317, a potent LXR agonist, is an inverse agonist of CAR. J Toxicol Sci. 2013;38(3):309-15.

T0901317 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.39mL

2.08mL

1.04mL

20.78mL

4.16mL

2.08mL

T0901317 技术信息

CAS号	293754-55-9
分子式	C₁₇H₁₂F₉NO₃S
分子量	481.333

别名
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(218.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(207.76 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 3 mg/mL clear

PO 0.5% CMC-Na 27 mg/mL suspension

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

CHO cells	Function assay		Agonist activity at human LXR beta receptor expressed in CHO cells by reporter assay, EC50=16 nM	19853462
COS7 cells	Function assay	16 h	Agonist activity at human LXRbeta receptor transfected in COS7 cells after 16 hrs by reporter transactivation assay, EC50=11 nM	17587573
CV1 cells	Function assay		Transactivation of LXRbeta (unknown origin) expressed in CV1 cells by luciferase reporter gene assay, EC50=0.14 μM	25435151
HEK293 cells	Function assay		Agonist activity at human LXRbeta in HEK293 cells assessed as Gal4 transactivation, EC50=19 nM	20350005
HepG2 cells	Function assay		Effect on SREBP1c gene expression in human HepG2 cells, EC50=0.061 μM	18973288
HuH7 cells	Function assay		Upregulation of SREB1c mRNA level in human HuH7 cells, EC50=0.036 μM	20382019
human H4 cells	Function assay		Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in Amyloid beta-42 formation LPECL assay, EC50=3.6 μM	17723298
mouse J774 cells	Function assay		Agonist activity at LXRbeta in mouse J774 cells assessed as upregulation of ABCA1 mRNA expression, EC50=0.027 μM	19853462
mouse J774A1 cells	Function assay	18 h	Induction of ABCA1 mRNA expression in mouse J774A1 cells after 18 hrs by RT-PCR, EC50=0,034 μM	19394832
SH-SY5Y cells	Function assay	24 h	Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assay, EC50=0.075 μM	19264481
THP1 cells	Function assay		Stimulation of [3H]cholesterol efflux in human THP1 foam cells loaded with ac-LDL, EC50=3 nM	19962892

T0901317 99%

T0901317 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

T0901317 质控信息

T0901317 生物活性

T0901317 细胞研究

T0901317 动物研究

T0901317 参考文献

T0901317 实验方案

T0901317 技术信息

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T0901317 99%

T0901317 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

T0901317 质控信息

T0901317 生物活性

T0901317 细胞研究

T0901317 动物研究

T0901317 参考文献

T0901317 实验方案

T0901317 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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T0901317 纯度/质量文件产品仅供科研