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桑尼菲拉姆 /Sunifiram {[allProObj[0].p_purity_real_show]}

货号：A519572 同义名： 桑尼非拉姆 / DM-235

Sunifiram is a piperazine derived ampakine-like drug(acting via AMPA receptors) which has nootropic effects in animal studies with significantly higher potency than piracetam.

Sunifiram 化学结构 CAS号：314728-85-3
Sunifiram 化学结构
CAS号：314728-85-3
Sunifiram 3D分子结构
CAS号：314728-85-3
Sunifiram 化学结构 CAS号：314728-85-3
Sunifiram 3D分子结构 CAS号：314728-85-3
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Sunifiram 纯度/质量文件 产品仅供科研

货号：A519572 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
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Sunifiram 生物活性

描述 Sunifiram (DM-235) is a nootropic compound that, unlike piracetam, exhibits significant potency in enhancing cognitive functions in animal models. Structurally akin to ampakines, it has been found to reverse amnesia induced by AMPA receptor antagonists without affecting motor coordination or spontaneous motility[1].
体内研究

Moreover, sunifiram enhances long-term potentiation (LTP) in mouse hippocampal slices at concentrations of 10-100 nM, with a peak effect at 10 nM. This enhancement is blocked by 7-chloro-kynurenic acid, a glycine-binding site antagonist of the NMDA receptor, suggesting its action involves modulation of NMDAR activity[2].

Furthermore, in experiments with olfactory bulbectomized (OBX) mice, daily administration of sunifiram (0.01-1.0 mg/kg orally) for 7-12 days post-operation demonstrated potential cognitive benefits, further emphasizing its action on NMDAR[3].

Sunifiram 参考文献

[1]Galeotti N, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):538-45.

[2]Moriguchi S, et al. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Jun 3.

[3]Moriguchi S, et al. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1;242:150-7.

Sunifiram 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.30mL

4.06mL

2.03mL

40.60mL

8.12mL

4.06mL

Sunifiram 技术信息

CAS号314728-85-3
分子式C14H18N2O2
分子量 246.305
别名 桑尼非拉姆 ;DM-235
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 2 mg/mL(8.12 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(203 mM)，配合低频超声助溶
动物实验配方

Tags: Sunifiram | 314728-85-3 | DM-235 | DM235 | DM 235 | iGluR Agonist | Membrane Transporter/Ion Channel | Neuronal Signaling | iGluR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Sunifiram 纯度/质量文件 | Sunifiram 生物活性 | Sunifiram 参考文献 | Sunifiram 实验方案 | Sunifiram 技术信息

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