Sunifiram

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Chemical Structure| 314728-85-3 同义名 : 桑尼非拉姆 ;DM-235
CAS号 : 314728-85-3
货号 : A519572
分子式 : C14H18N2O2
纯度 : 98%
分子量 : 246.305
MDL号 : MFCD04112755
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(8.12 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(203 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Sunifiram (DM-235) is a nootropic compound that, unlike piracetam, exhibits significant potency in enhancing cognitive functions in animal models. Structurally akin to ampakines, it has been found to reverse amnesia induced by AMPA receptor antagonists without affecting motor coordination or spontaneous motility[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.30mL

4.06mL

2.03mL

40.60mL

8.12mL

4.06mL
参考文献

[1]Galeotti N, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):538-45.

[2]Moriguchi S, et al. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Jun 3.

[3]Moriguchi S, et al. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1;242:150-7.