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磺胺对甲氧嘧啶 /Sulfameter {[allProObj[0].p_purity_real_show]}

货号：A108984 同义名： 磺胺-5-甲氧嘧啶 / Sulfametoxydiazine;5-Methoxysulfadiazine

Sulfameter a long-acting sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections, which blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase as a competitive inhibitors of bacterial para-aminobenzoic acid.

Sulfameter 化学结构 CAS号：651-06-9
Sulfameter 化学结构
CAS号：651-06-9
Sulfameter 3D分子结构
CAS号：651-06-9
Sulfameter 化学结构 CAS号：651-06-9
Sulfameter 3D分子结构 CAS号：651-06-9
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Sulfameter 纯度/质量文件 产品仅供科研

货号：A108984 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Sulfameter 生物活性

描述 Sulfameter is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent in the treatment of urinary tract infections[3]. Sulfameter is also a potential antimalarial agents and 100% curative in test conditions[4]. The sorption coefficient Kd,s values revealed that sulfameter, sulfadiazine, sulfamethoxypyridazine, sulfamonomethoxine, chloramphenicol, and doxycycline presented higher sorption capacities than the other antibiotics[5]. P. carinii infection was prevented in all animals (100%) receiving dosages of as little as 1.0 mg of sulfamethoxazole, sulfamethoxypyridazine, and sulfadimethoxine per kg per day, as little as 10 mg of sulfameter, sulfachlorpyridazine, and sulfaquinoxaline per kg per day; and 100 mg of sulfaguanidine and sulfanilamide per kg per day[6].

Sulfameter 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03720561 - Recruiting November 29, 2021 Italy ... 展开 >> U.O.C. Ematologia e Terapia Cellulare Ospedale C e G Mazzoni Not yet recruiting Ascoli Piceno, Italy, 63100 U.O. Ematologia con Trapianto- AOU Policlinico di Bari Not yet recruiting Bari, Italy, 70124 U.O. Ematologia Istituto Tumori Giovanni Paolo II Recruiting Bari, Italy, 70124 S.C. Ematologia e CTMO P.O. Businco A.O. Brotzu Not yet recruiting Cagliari, Italy, 09121 Div.Clinicizzata EmatologiaconTrapiantodi MidolloOsseo P.O.Rodoligo AOUPoliclinico-Vittorio Emanuele Not yet recruiting Catania, Italy, 95124 S.O.C. Ematologia P.O. Ciaccio A.O. Pugliese-Ciaccio Recruiting Catanzaro, Italy, 88100 Azienda Ospedaliero Universitaria di Ferrara Not yet recruiting Cona, Italy, 44124 S.C. Ematologia Azienda Ospedaliera S. Croce e Carle Not yet recruiting Cuneo, Italy, 12100 Unità Funzionale di Ematologia Azienda ospedaliero-universitaria Careggi Not yet recruiting Firenze, Italy, 50134 S.C. Ematologia A.O.U. Ospedali Riuniti Not yet recruiting Foggia, Italy, 71100 Ematologia Ospedale San Martino Not yet recruiting Genova, Italy, 16132 U.O.C. Ematologia Ospedale V. Fazzi Recruiting Lecce, Italy, 73100 U.O.C. Ematologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Not yet recruiting Milano, Italy, 20122 Programma di ricerca strategica sulla LLC Ospedale San Raffaele Not yet recruiting Milano, Italy, 20132 Divisione ematologia Grande Ospedale Metropolitano Niguarda Not yet recruiting Milano, Italy, 20133 Division of Hematology, Cardarelli Hospital Recruiting Napoli, Italy, 80131 U.O.C. Ematologia e Trapianti di midollo A.O.U. Federico II Not yet recruiting Napoli, Italy, 80131 U.O.C. Ematologia e Immunologia Clinica Azienda Ospedaliera Padova Not yet recruiting Padova, Italy, 35128 U.O. Ematologia ed Oncologia Ospedale A. Tortora Not yet recruiting Pagani, Italy, 84016 Ospedale 'Villa Sofia-Cervello Not yet recruiting Palermo, Italy, 90146 Fondazione IRCCS Policlinico San Matteo Not yet recruiting Pavia, Italy, 27100 S.C. Ematologia A.O.U. Santa Maria della Misericordia Not yet recruiting Perugia, Italy, 06132 UOSD Centro diagnosi e terapia dei linfomi Ospedale Santo Spirito Not yet recruiting Pescara, Italy, 65124 U.O.C. Ematologia Ospedale S. Maria delle Croci Not yet recruiting Ravenna, Italy, 48121 Arcispedale Santa Maria Nuova - IRCCS Not yet recruiting Reggio Emilia, Italy, 42123 DH Oncoematologia Policlinico Tor Vergata Not yet recruiting Roma, Italy, 00133 Ematologia Fondazione Univ. Policlinico Gemelli Università Cattolica del Sacro Cuore Not yet recruiting Roma, Italy, 00168 Azienda Ospedaliera Sant Andrea Not yet recruiting Roma, Italy, 189 UO Oncologia ed Ematologia Istituto Clinico Humanitas Not yet recruiting Rozzano, Italy, 20089 U.O.C. Ematologia e Trapianti Cellule Staminali Emopoietiche AOU S.Giovanni di Dio e Ruggi D'Aragona Not yet recruiting Salerno, Italy, 84131 Ospedale 'Casa Sollievo della Sofferenza' - U.O. Ematologia- Not yet recruiting San Giovanni Rotondo, Italy, 71013 Azienda Ospedaliera 'Santa Maria' Not yet recruiting Terni, Italy S.C. Ematologia U A.O.U. Citta della Salute e della Scienza P.O.Molinette Not yet recruiting Torino, Italy, 10126 U.O. Ematologia Ospedale San Bortolo Not yet recruiting Vicenza, Italy, 36100 收起 <<
NCT00687466 Cystic Fibrosis ... 展开 >> Glucose Intolerance 收起 << Phase 3 Unknown October 2009 Italy ... 展开 >> Pediatric Department, General Hospital,CF Center Cerignola (Foggia), Italy Ospedale Maggiore Policlinico, Adult CF Center Milano, Italy Pediatric Department, Federico II University, Pediatric CF Center Napoli, Italy Pediatric Department G.De Cristina Hospital CF Center Palermo, Italy Bambino Gesù Hospital CF Center Roma, Italy Policlinico Umberto I. CF Center Roma, Italy 收起 <<
NCT01523652 - Completed - Italy ... 展开 >> ASO Ordine Mauriziano Turin, Italy 收起 <<

Sulfameter 参考文献

[1]Kaumeier S. The effect of the composition of food on the absorption of sulfameter. Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):260-3.

[2]Robins AH. Sulfameter (Sulla). Clin Pharmacol Ther. 1969 Jul-Aug;10(4):591-4.

[3]Sulfameter (Sulla) - a long-acting sulfonamide. Med Lett Drugs Ther. 1968;10(16):61–62.

[4]Ohara MT, Sakuda T, Cruz M, Ferreira E, Korolkovas A. Antimalarial activity of oxidized starch and cellulose imine derivatives. Boll Chim Farm. 1995;134(9):522–527.

[5]Na G, Fang X, Cai Y, et al. Occurrence, distribution, and bioaccumulation of antibiotics in coastal environment of Dalian, China. Mar Pollut Bull. 2013;69(1-2):233–237.

[6]Hughes WT, Killmar J. Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1996;40(4):962–965.

Sulfameter 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.57mL

0.71mL

0.36mL

17.84mL

3.57mL

1.78mL

35.68mL

7.14mL

3.57mL

Sulfameter 技术信息

CAS号651-06-9
分子式C11H12N4O3S
分子量 280.3
别名 磺胺-5-甲氧嘧啶 ;Sulfametoxydiazine;5-Methoxysulfadiazine;I-2586;Solfametossidiazina [DCIT];Sulfametoxipirimidine;SH 613;Sulfamethoxydiazine;NSC 683528;Bayrena
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 105 mg/mL(374.59 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Sulfameter | Sulfametoxydiazine | 磺胺-5-甲氧嘧啶 | Sulfonamide | Antibacterial | AmBeed-信号通路专用抑制剂 | Sulfameter 纯度/质量文件 | Sulfameter 生物活性 | Sulfameter 临床数据 | Sulfameter 参考文献 | Sulfameter 实验方案 | Sulfameter 技术信息

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