产品说明书
Sulfameter
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同义名 : | 磺胺-5-甲氧嘧啶 ;Sulfametoxydiazine;5-Methoxysulfadiazine;I-2586;Solfametossidiazina [DCIT];Sulfametoxipirimidine;SH 613;Sulfamethoxydiazine;NSC 683528;Bayrena |
| CAS号 : | 651-06-9 | |
| 货号 : | A108984 | |
| 分子式 : | C11H12N4O3S | |
| 纯度 : | 98+% | |
| 分子量 : | 280.3 | |
| MDL号 : | MFCD00006067 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(374.59 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sulfameter is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent in the treatment of urinary tract infections[3]. Sulfameter is also a potential antimalarial agents and 100% curative in test conditions[4]. The sorption coefficient Kd,s values revealed that sulfameter, sulfadiazine, sulfamethoxypyridazine, sulfamonomethoxine, chloramphenicol, and doxycycline presented higher sorption capacities than the other antibiotics[5]. P. carinii infection was prevented in all animals (100%) receiving dosages of as little as 1.0 mg of sulfamethoxazole, sulfamethoxypyridazine, and sulfadimethoxine per kg per day, as little as 10 mg of sulfameter, sulfachlorpyridazine, and sulfaquinoxaline per kg per day; and 100 mg of sulfaguanidine and sulfanilamide per kg per day[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03720561 | - | Recruiting | November 29, 2021 | Italy ... 展开 >> U.O.C. Ematologia e Terapia Cellulare Ospedale C e G Mazzoni Not yet recruiting Ascoli Piceno, Italy, 63100 U.O. Ematologia con Trapianto- AOU Policlinico di Bari Not yet recruiting Bari, Italy, 70124 U.O. Ematologia Istituto Tumori Giovanni Paolo II Recruiting Bari, Italy, 70124 S.C. Ematologia e CTMO P.O. Businco A.O. Brotzu Not yet recruiting Cagliari, Italy, 09121 Div.Clinicizzata EmatologiaconTrapiantodi MidolloOsseo P.O.Rodoligo AOUPoliclinico-Vittorio Emanuele Not yet recruiting Catania, Italy, 95124 S.O.C. Ematologia P.O. Ciaccio A.O. Pugliese-Ciaccio Recruiting Catanzaro, Italy, 88100 Azienda Ospedaliero Universitaria di Ferrara Not yet recruiting Cona, Italy, 44124 S.C. Ematologia Azienda Ospedaliera S. Croce e Carle Not yet recruiting Cuneo, Italy, 12100 Unità Funzionale di Ematologia Azienda ospedaliero-universitaria Careggi Not yet recruiting Firenze, Italy, 50134 S.C. Ematologia A.O.U. Ospedali Riuniti Not yet recruiting Foggia, Italy, 71100 Ematologia Ospedale San Martino Not yet recruiting Genova, Italy, 16132 U.O.C. Ematologia Ospedale V. Fazzi Recruiting Lecce, Italy, 73100 U.O.C. Ematologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Not yet recruiting Milano, Italy, 20122 Programma di ricerca strategica sulla LLC Ospedale San Raffaele Not yet recruiting Milano, Italy, 20132 Divisione ematologia Grande Ospedale Metropolitano Niguarda Not yet recruiting Milano, Italy, 20133 Division of Hematology, Cardarelli Hospital Recruiting Napoli, Italy, 80131 U.O.C. Ematologia e Trapianti di midollo A.O.U. Federico II Not yet recruiting Napoli, Italy, 80131 U.O.C. Ematologia e Immunologia Clinica Azienda Ospedaliera Padova Not yet recruiting Padova, Italy, 35128 U.O. Ematologia ed Oncologia Ospedale A. Tortora Not yet recruiting Pagani, Italy, 84016 Ospedale 'Villa Sofia-Cervello Not yet recruiting Palermo, Italy, 90146 Fondazione IRCCS Policlinico San Matteo Not yet recruiting Pavia, Italy, 27100 S.C. Ematologia A.O.U. Santa Maria della Misericordia Not yet recruiting Perugia, Italy, 06132 UOSD Centro diagnosi e terapia dei linfomi Ospedale Santo Spirito Not yet recruiting Pescara, Italy, 65124 U.O.C. Ematologia Ospedale S. Maria delle Croci Not yet recruiting Ravenna, Italy, 48121 Arcispedale Santa Maria Nuova - IRCCS Not yet recruiting Reggio Emilia, Italy, 42123 DH Oncoematologia Policlinico Tor Vergata Not yet recruiting Roma, Italy, 00133 Ematologia Fondazione Univ. Policlinico Gemelli Università Cattolica del Sacro Cuore Not yet recruiting Roma, Italy, 00168 Azienda Ospedaliera Sant Andrea Not yet recruiting Roma, Italy, 189 UO Oncologia ed Ematologia Istituto Clinico Humanitas Not yet recruiting Rozzano, Italy, 20089 U.O.C. Ematologia e Trapianti Cellule Staminali Emopoietiche AOU S.Giovanni di Dio e Ruggi D'Aragona Not yet recruiting Salerno, Italy, 84131 Ospedale 'Casa Sollievo della Sofferenza' - U.O. Ematologia- Not yet recruiting San Giovanni Rotondo, Italy, 71013 Azienda Ospedaliera 'Santa Maria' Not yet recruiting Terni, Italy S.C. Ematologia U A.O.U. Citta della Salute e della Scienza P.O.Molinette Not yet recruiting Torino, Italy, 10126 U.O. Ematologia Ospedale San Bortolo Not yet recruiting Vicenza, Italy, 36100 收起 << | |
| NCT00687466 | Cystic Fibrosis ... 展开 >> Glucose Intolerance 收起 << | Phase 3 | Unknown | October 2009 | Italy ... 展开 >> Pediatric Department, General Hospital,CF Center Cerignola (Foggia), Italy Ospedale Maggiore Policlinico, Adult CF Center Milano, Italy Pediatric Department, Federico II University, Pediatric CF Center Napoli, Italy Pediatric Department G.De Cristina Hospital CF Center Palermo, Italy Bambino Gesù Hospital CF Center Roma, Italy Policlinico Umberto I. CF Center Roma, Italy 收起 << |
| NCT01523652 | - | Completed | - | Italy ... 展开 >> ASO Ordine Mauriziano Turin, Italy 收起 << | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.57mL 0.71mL 0.36mL |
17.84mL 3.57mL 1.78mL |
35.68mL 7.14mL 3.57mL |
| 参考文献 |
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[2]Robins AH. Sulfameter (Sulla). Clin Pharmacol Ther. 1969 Jul-Aug;10(4):591-4. [3]Sulfameter (Sulla) - a long-acting sulfonamide. Med Lett Drugs Ther. 1968;10(16):61–62. |