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Sodium 4-Aminosalicylate Dihydrate

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Chemical Structure| 6018-19-5 同义名 : 对氨基水杨酸钠二水合物 ;4-Aminosalicylic acid sodium salt dihydrate;Sodium 4-Aminosalicylate
CAS号 : 6018-19-5
货号 : A200669
分子式 : C7H10NNaO5
纯度 : 98%
分子量 : 211.148
MDL号 : MFCD00151044
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(497.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(473.6 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • NF-κB
描述 Sodium 4-aminosalicylate dihydrate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis[3]. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity[4]. Mimicking the host environment in terms of iron availability should be considered for in vitro susceptibility testing of mycobacteria, especially for antibiotics interfering with iron metabolism, such as 4-aminosalicylate[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.74mL

0.95mL

0.47mL

23.68mL

4.74mL

2.37mL

47.36mL

9.47mL

4.74mL
参考文献

[1]Dinis TC, Maderia VM, Almeida LM. Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch Biochem Biophys. 1994 Nov 15;315(1):161-9.

[2]Dull BJ, Salata K, et al. 5-Aminosalicylate: oxidation by activated leukocytes and protection of cultured cells from oxidative damage. Biochem Pharmacol. 1987 Aug 1;36(15):2467-72.

[3]Zheng J, Rubin EJ, Bifani P, et al. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013;288(32):23447–23456

[4]Aldabaldetrecu M, Tamayo L, Alarcon R, et al. Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects. Molecules. 2018;23(7):1629.

[5]Kopinc R, Lapanje A. Antibiotic susceptibility profile of Mycobacterium avium subspecies hominissuis is altered in low-iron conditions. J Antimicrob Chemother. 2012;67(12):2903–2907