LCZ 696 is a mixture of neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan in a ratio of 1:1.
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Angiotensin receptor blockade and neprilysin (NEP) inhibition together offer potential benefits for the treatment of hypertension and heart failure. LCZ696, composed of valsartan and sacubitril with a molar ratio of 1:1, is an oral bioactive, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for the treatment of hypertension and heart failure[3]. H9C2 cells were pretreated with LCZ696 at concentrations of 1, 10, or 30 μM for 30 min and then stimulated with high glucose (HG) for 48 h. HG- or diabetes-induced JNK/p38MAPK phosphorylation and NF-kB nuclear translocation were inhibited by the administration of LCZ696[4]. Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats[3]. Adult male Sprague–Dawley rats were randomized to treatment for 4 weeks with LCZ696 (68 mg/kg body weight perorally; myocardial infarction (MI) -ARNi, n=11), and the degree of fibrosis both in noninfarcted remote myocardium and in the peri-infarct zone was significantly reduced[5].
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