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3-巯基吡啶-2-甲酸盐酸盐 /SKF-34288 HCl {[allProObj[0].p_purity_real_show]}

货号：A758333 同义名： 3 - 巯基吡啶甲酸 / 3-Mercaptopicolinic acid hydrochloride;3-MPA hydrochloride

SKF-34288 HCl is a PEPCK inhibitor which could inhibit glucose synthesis through inhibition of PEPCK in the gluconeogenesis pathway.

SKF-34288 HCl 化学结构 CAS号：320386-54-7
SKF-34288 HCl 化学结构
CAS号：320386-54-7
SKF-34288 HCl 3D分子结构
CAS号：320386-54-7
SKF-34288 HCl 化学结构 CAS号：320386-54-7
SKF-34288 HCl 3D分子结构 CAS号：320386-54-7
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SKF-34288 HCl 纯度/质量文件 产品仅供科研

货号：A758333 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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SKF-34288 HCl 生物活性

描述 PEPCK (phosphoenolpyruvate carboxykinase) has a key role in highly gluconeogenic tissues such as liver and kidney, converting lactateand other precursors to glucose and releasing the sugar into the bloodstream. SKF-34288 HCl is a PEPCK inhibitor which is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway[1]. Supplying MPA decreased xylem recycling in the leaf as there was an increase in the amount of amino acids, 2cm from the base and at the tip. Feeding MPA increased the volume of the xylem exudate and guttation fluid in the control leaves, except at the base. Feeding MPA clearly inhibited Asn metabolism and resulted in an increase in amino acids and amides in the xylem[2].
作用机制 Binding of SKF-34288 to the allosteric pocket stabilizes an altered conformation of the nucleotide-binding site that in turn reduces the affinity of the enzyme for the nucleotide[1].

SKF-34288 HCl 参考文献

[1]Balan MD, et al. Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry. 2015 Sep 29;54(38):5878-87

[2]Bailey KJ, et al. Nitrogen recycling from the xylem in rice leaves: dependence upon metabolism and associated changes in xylem hydraulics. J Exp Bot. 2016 Apr;67(9):2901-11

SKF-34288 HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.22mL

1.04mL

0.52mL

26.09mL

5.22mL

2.61mL

52.18mL

10.44mL

5.22mL

SKF-34288 HCl 技术信息

CAS号320386-54-7
分子式C6H6ClNO2S
分子量 191.635
别名 3 - 巯基吡啶甲酸 ;3-Mercaptopicolinic acid hydrochloride;3-MPA hydrochloride;hydrochloride;3-sulfanylpyridine-2-carboxylic acid;SKF-34288 (hydrochloride);SKF 34288;3-Mercaptopicolinic Acid (hydrochloride);SKF-34288 hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

H2O: 5 mg/mL(26.09 mM)，配合低频超声助溶
动物实验配方

Tags: SKF-34288 | 320386-54-7 | 3-Mercaptopicolinic acid | 3-MPA | SKF34288 | SKF 34288 | PEPCK | Phosphoenolpyruvate Carboxykinase | C2C12 | glucose synthesis | hypoglycemic | blood glucose | PEPCK Inhibitor | Metabolic Enzyme/Protease | PEPCK | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | SKF-34288 HCl 纯度/质量文件 | SKF-34288 HCl 生物活性 | SKF-34288 HCl 参考文献 | SKF-34288 HCl 实验方案 | SKF-34288 HCl 技术信息

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