SKF-34288 HCl | 3 - 巯基吡啶甲酸 | 3-Mercaptopicolinic acid hydrochloride | PEPCK Inhibitor

首页 / 抑制剂/激动剂 / 代谢酶 / PEPCK / SKF-34288 HCl

3-巯基吡啶-2-甲酸盐酸盐 /SKF-34288 HCl {[allProObj[0].p_purity_real_show]}

货号：A758333 同义名： 3 - 巯基吡啶甲酸 / 3-Mercaptopicolinic acid hydrochloride;3-MPA hydrochloride

SKF-34288 HCl is a PEPCK inhibitor which could inhibit glucose synthesis through inhibition of PEPCK in the gluconeogenesis pathway.

SKF-34288 HCl 化学结构
CAS号：320386-54-7

SKF-34288 HCl 3D分子结构
CAS号：320386-54-7

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

SKF-34288 HCl 纯度/质量文件产品仅供科研

货号：A758333 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

SKF-34288 HCl 生物活性

描述

PEPCK (phosphoenolpyruvate carboxykinase) has a key role in highly gluconeogenic tissues such as liver and kidney, converting lactateand other precursors to glucose and releasing the sugar into the bloodstream. SKF-34288 HCl is a PEPCK inhibitor which is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway^[1]. Supplying MPA decreased xylem recycling in the leaf as there was an increase in the amount of amino acids, 2cm from the base and at the tip. Feeding MPA increased the volume of the xylem exudate and guttation fluid in the control leaves, except at the base. Feeding MPA clearly inhibited Asn metabolism and resulted in an increase in amino acids and amides in the xylem^[2].

作用机制

Binding of SKF-34288 to the allosteric pocket stabilizes an altered conformation of the nucleotide-binding site that in turn reduces the affinity of the enzyme for the nucleotide^[1].

SKF-34288 HCl 参考文献

[1]Balan MD, et al. Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry. 2015 Sep 29;54(38):5878-87

[2]Bailey KJ, et al. Nitrogen recycling from the xylem in rice leaves: dependence upon metabolism and associated changes in xylem hydraulics. J Exp Bot. 2016 Apr;67(9):2901-11

SKF-34288 HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

5.22mL

1.04mL

0.52mL

26.09mL

5.22mL

2.61mL

52.18mL

10.44mL

5.22mL

SKF-34288 HCl 技术信息

CAS号	320386-54-7
分子式	C₆H₆ClNO₂S
分子量	191.635

别名	3 - 巯基吡啶甲酸 ;3-Mercaptopicolinic acid hydrochloride;3-MPA hydrochloride;hydrochloride;3-sulfanylpyridine-2-carboxylic acid;SKF-34288 (hydrochloride);SKF 34288;3-Mercaptopicolinic Acid (hydrochloride);SKF-34288 hydrochloride
运输	蓝冰

存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

H₂O: 5 mg/mL(26.09 mM)，配合低频超声助溶

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

3-巯基吡啶-2-甲酸盐酸盐 /SKF-34288 HCl {[allProObj[0].p_purity_real_show]}

SKF-34288 HCl 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

SKF-34288 HCl 质控信息

SKF-34288 HCl 生物活性

SKF-34288 HCl 参考文献

SKF-34288 HCl 实验方案

SKF-34288 HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

3-巯基吡啶-2-甲酸盐酸盐 /SKF-34288 HCl {[allProObj[0].p_purity_real_show]}

SKF-34288 HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

SKF-34288 HCl 质控信息

SKF-34288 HCl 生物活性

SKF-34288 HCl 参考文献

SKF-34288 HCl 实验方案

SKF-34288 HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

SKF-34288 HCl 纯度/质量文件产品仅供科研