产品说明书
SKF-34288 HCl
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同义名 : | 3 - 巯基吡啶甲酸 ;3-Mercaptopicolinic acid hydrochloride;3-MPA hydrochloride;hydrochloride;3-sulfanylpyridine-2-carboxylic acid;SKF-34288 (hydrochloride);SKF 34288;3-Mercaptopicolinic Acid (hydrochloride);SKF-34288 hydrochloride |
| CAS号 : | 320386-54-7 | |
| 货号 : | A758333 | |
| 分子式 : | C6H6ClNO2S | |
| 纯度 : | 95% | |
| 分子量 : | 191.635 | |
| MDL号 : | MFCD01320417 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 5 mg/mL(26.09 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | PEPCK (phosphoenolpyruvate carboxykinase) has a key role in highly gluconeogenic tissues such as liver and kidney, converting lactateand other precursors to glucose and releasing the sugar into the bloodstream. SKF-34288 HCl is a PEPCK inhibitor which is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway[1]. Supplying MPA decreased xylem recycling in the leaf as there was an increase in the amount of amino acids, 2cm from the base and at the tip. Feeding MPA increased the volume of the xylem exudate and guttation fluid in the control leaves, except at the base. Feeding MPA clearly inhibited Asn metabolism and resulted in an increase in amino acids and amides in the xylem[2]. | ||
| 作用机制 | Binding of SKF-34288 to the allosteric pocket stabilizes an altered conformation of the nucleotide-binding site that in turn reduces the affinity of the enzyme for the nucleotide[1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.22mL 1.04mL 0.52mL |
26.09mL 5.22mL 2.61mL |
52.18mL 10.44mL 5.22mL |
| 参考文献 |
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