货号:A508148 同义名: 磺丁基-β-环糊精钠盐 / Sulfobutylether-β-Cyclodextrin;Captisol
SBE-β-CD是一种β-环糊精的衍生物,可作为助溶剂,增加难溶性活性分子的溶解度,被广泛用于生物学实验中。SBE-β-CD可以与药物分子形成非共价包合物,从而提高药物的稳定性、溶解度和安全性,降低毒性,掩盖不良气味,控制药物释放速率。
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描述 | SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents. SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range[1]. The pharmacokinetic profile and renal clearance of a novel synthetic ozonide antimalarial was found to be significantly altered when intravenously administered to rats as a cyclodextrin-based formulation (0.1 M Captisol, a sulfobutylether beta-cyclodextrin derivative (SBE(7)-beta-CD)) compared to a cyclodextrin-free isotonic buffered glucose formulation[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
0.69mL 0.14mL 0.07mL |
3.45mL 0.69mL 0.34mL |
6.89mL 1.38mL 0.69mL |
CAS号 | 182410-00-0 |
分子式 | |
分子量 |
别名 | 磺丁基-β-环糊精钠盐 ;Sulfobutylether-β-Cyclodextrin;Captisol;Captisol. beta-cyclodextrin sulfobutyl ether sodium salts.;Sulfobutylether beta-cyclodextrin;SBE-beta-CD |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,Room Temperature |
溶解度 | |
动物实验配方 |