产品说明书

SBE-β-CD

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Chemical Structure| 182410-00-0 同义名 : 磺丁基-β-环糊精钠盐 ;Sulfobutylether-β-Cyclodextrin;Captisol;Captisol. beta-cyclodextrin sulfobutyl ether sodium salts.;Sulfobutylether beta-cyclodextrin;SBE-beta-CD
CAS号 : 182410-00-0
货号 : A508148
分子式 : -
纯度 : 98%
分子量 : 0
MDL号 : MFCD12032209
存储条件:

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents. SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range[1]. The pharmacokinetic profile and renal clearance of a novel synthetic ozonide antimalarial was found to be significantly altered when intravenously administered to rats as a cyclodextrin-based formulation (0.1 M Captisol, a sulfobutylether beta-cyclodextrin derivative (SBE(7)-beta-CD)) compared to a cyclodextrin-free isotonic buffered glucose formulation[2].
参考文献

[1]Fukuda M, Miller DA, Peppas NA, McGinity JW. Influence of sulfobutyl ether beta-cyclodextrin (Captisol) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion. Int J Pharm. 2008 Feb 28;350(1-2):188-96

[2]Charman SA, Perry CS, Chiu FC, McIntosh KA, Prankerd RJ, Charman WN. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006 Feb;95(2):256-67