There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
SB 452533 is a potent antagonist of the recombinant rat TRPV1 receptor cloned in HEK293 cells, with a pKb value of 7.7 and a pIC50 value of 7.0[1].SB 452533 reduces phosphorylation of CAMKK2 and AMPK[2].In skeletal muscle cells C2C12, SB 452533 at concentrations of 50, 100, 200 and 400 μM was applied for 30 min, followed by treatment of the cells with 200 μM capsaicin for 30 min. The results showed that SB 452533 significantly reduced capsaicin-induced phosphorylation of AMPK and CAMKK2.
SB 452533 动物研究
Animal study
Capsaicin (2 mg/kg) significantly attenuated Bleomycin-induced lung fibrosis in BALB/c mice, whereas SB-452533 abrogated this effect[3].
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