Ribostamycin Sulfate is a broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus, which acts through binding to the bacterial 30S and 50S ribosomal subunit , inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and thus causing misreading of mRNA.
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Ribostamycin Sulfate is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding. The binding affinity of ribostamycin to purified bovine PDI (protein disulfide isomerase) was 319 μM (K(D) value)[3]. Moreover, MIC(90) of ribostamycin is 32 mg/L)[4]. The linear relationship of ribostamycin sulfate and kanamycin between concentration and peak height was obtained in the concentration range of 0.18-1.08 mM and 0.31-1.86 mM and the determination limit was 7. 2 nM and 46 nM respectively[5]. The Cmax in children and infants after intramuscular ribostamycin 10 mg/kg approached that in adults after an intramuscular dose of ribostamycin 500 mg. It is suggested that ribostamycin was administered in intramuscular doses of 10 to 15 mg/kg twice daily in infants and 3 times daily in children, respectively[6].
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