产品说明书
Ribostamycin Sulfate
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同义名 : | Vistamycin sulfate |
| CAS号 : | 53797-35-6 | |
| 货号 : | A391931 | |
| 分子式 : | C17H36N4O14S | |
| 纯度 : | 98% | |
| 分子量 : | 552.551 | |
| MDL号 : | MFCD23380549 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 120 mg/mL(217.17 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ribostamycin Sulfate is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding. The binding affinity of ribostamycin to purified bovine PDI (protein disulfide isomerase) was 319 μM (K(D) value)[3]. Moreover, MIC(90) of ribostamycin is 32 mg/L)[4]. The linear relationship of ribostamycin sulfate and kanamycin between concentration and peak height was obtained in the concentration range of 0.18-1.08 mM and 0.31-1.86 mM and the determination limit was 7. 2 nM and 46 nM respectively[5]. The Cmax in children and infants after intramuscular ribostamycin 10 mg/kg approached that in adults after an intramuscular dose of ribostamycin 500 mg. It is suggested that ribostamycin was administered in intramuscular doses of 10 to 15 mg/kg twice daily in infants and 3 times daily in children, respectively[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.81mL 0.36mL 0.18mL |
9.05mL 1.81mL 0.90mL |
18.10mL 3.62mL 1.81mL |
| 参考文献 |
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