货号:A111785
同义名:
利巴韦林
/ Ribasphere;NSC 163039
Ribavirin blocks nucleic acid synthesis and inhibits both RNA and DNA viruses. Ribavirin is a nucleoside antimetabolite antiviral agent.
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | Hepatitis C virus (HCV) is an enveloped, single-stranded, positive-sense RNA virus in the Flaviviridae family and is the leading cause of cirrhosis and need for liver transplantation. Ribavirin is a nucleoside analogue and broad spectrum antiviral agent that is used with pegylated IFN (Peg-IFN) for HCV treatment. Although ribavirin does not have significant antiviral effect when used alone, it does reduce the number of break-throughs and relapses when used in combination with Peg-IFN. In a mouse model, ribavirin treatment inhibited macrophage inflammatory cytokine response resulting in reduction in alanine aminotransferase (ALT) and histological improvement suggesting ribavirin may act on HCV via an immunomodulatory route. Studies combining IFN-α (used for the treatment of HCV) and ribavirin for 24 or 48 weeks showed increasing proportion of SVR (sustained virologic response) with longer duration and addition of ribavirin suggesting the important role ribavirin plays in improving SVR[3]. |
作用机制 | By depleting endogenous GTP, ribavirin is preferentially incorporated into the growing HCV viral strand leading to reduced viral replication[3]. |
细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
african green monkey Vero cells | Function assay | 5 days | Antiviral activity against RSV A2 infected in african green monkey Vero cells after 5 days by plaque reduction assay, EC50=7 μM | 20359898 | |
BHK21 cell line | Function assay | Inhibition of West Nile virus VLP replicon in BHK21 cell line, EC50=1.1 μM | 16539402 | ||
E6SM cell lines | Function assay | Effective concentration required to inhibit Herpes simplex virus-1(HSV-1) / thymine kinase deficient (TK-)B2006 / VMW1837 induced cytopathicity by 50% in E6SM cell lines, EC50=0.005 μM | 11495586 | ||
HEK293 cells | Function assay | 24 h | Inhibition of influenza A virus RNA-dependent RNA polymerase expressed in HEK293 cells after 24 hrs by dual luciferase reporter gene assay, EC50=15 μM | 24313730 | |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
4.09mL 0.82mL 0.41mL |
20.47mL 4.09mL 2.05mL |
40.95mL 8.19mL 4.09mL |
CAS号 | 36791-04-5 |
分子式 | C8H12N4O5 |
分子量 | 244.205 |
别名 | 利巴韦林 ;Ribasphere;NSC 163039;Ribavirin, Copegus, Rebetol, Virazole, ICN-1229;Tribavirin;RTCA;ICN-1229 |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(429.97 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL(409.49 mM),配合低频超声助溶 |
动物实验配方 |