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闹羊花素 Ⅲ /Rhodojaponin III {[allProObj[0].p_purity_real_show]}

货号:A517712 同义名: 闹羊花毒素III

Rhodojaponin III is isolated from the herbs of Rhododendron molle G. Don which has antifeedant and oviposition deterrence effects against many kinds of insects.

Rhodojaponin III 化学结构 CAS号:26342-66-5
Rhodojaponin III 化学结构
CAS号:26342-66-5
Rhodojaponin III 3D分子结构
CAS号:26342-66-5
Rhodojaponin III 化学结构 CAS号:26342-66-5
Rhodojaponin III 3D分子结构 CAS号:26342-66-5
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Rhodojaponin III 纯度/质量文件 产品仅供科研

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Rhodojaponin III 生物活性

描述 Rhodojaponin III (R-III) is a bioactive diterpenoid isolated from the medicinal plant Rhododendron molle G. Don. Rhodojaponin III had fast oral absorption (time to peak concentration, 0.08 h) and good oral bioavailability (73.6%). In addition, rhodojaponin III was quickly eliminated after it was intravenously or orally administered, with half-life values of 0.19 and 0.76 h, respectively. After oral administration, it was widely distributed in tissues including kidney, lung, heart, spleen and thymus, but had extremely low concentrations in liver and brain[1]. R-III strongly inhibited Sf9 cells proliferation with a time- and dose-dependent manner. R-III induced a significant dose-dependent (1, 10, 100, 200 μg/mL) increase in [Ca2+](i) and pH(i) of Sf9 cells in presence of Ca2+-containing solution (Hanks) and an irreversible decrease in the absence of extra cellular Ca2+[2]. R-III showed an almost 30 times higher contact toxicity against third instars than for fifth instars, and the median lethal dose (LD50) values for topical application were 1.18 and 34.09 mg/kg at 72 h after treatment respectively. R-III disrupted the development of larvae to pupae or adults with median concentration for inhibiting growth (IC50) values of only 1.36 mg/L for third instars and 11.28 mg/L for fifth instars[3].

Rhodojaponin III 参考文献

[1]Zhang JQ, Zhao CC, Yang QY, Liang S, Wu F, Ma BL, Feng Y. Pharmacokinetics, bioavailability and tissue distribution studies of rhodojaponin III in mice using QTRAP LC-MS/MS. Biomed Chromatogr. 2019 Nov;33(11):e4649

[2]Cheng XA, Xie JJ, Hu MY, Zhang YB, Huang JF. Induction of intracellular Ca2+ and pH changes in Sf9 insect cells by rhodojaponin-III, a natural botanic insecticide isolated from Rhododendron molle. Molecules. 2011 Apr 15;16(4):3179-96

[3]Zhong G, Liu J, Weng Q, Hu M, Luo J. Laboratory and field evaluations of rhodojaponin-III against the imported cabbage worm Pieris rapae (L.) (Lepidoptera: Pieridae). Pest Manag Sci. 2006 Oct;62(10):976-81

Rhodojaponin III 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.57mL

2.71mL

1.36mL

27.14mL

5.43mL

2.71mL

Rhodojaponin III 技术信息

CAS号26342-66-5
分子式C20H32O6
分子量 368.464
别名 闹羊花毒素III
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度
动物实验配方
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