产品说明书
Rhodojaponin III
 |
同义名 : | 闹羊花毒素III |
| CAS号 : | 26342-66-5 | |
| 货号 : | A517712 | |
| 分子式 : | C20H32O6 | |
| 纯度 : | 98% | |
| 分子量 : | 368.464 | |
| MDL号 : | MFCD01714943 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Rhodojaponin III (R-III) is a bioactive diterpenoid isolated from the medicinal plant Rhododendron molle G. Don. Rhodojaponin III had fast oral absorption (time to peak concentration, 0.08 h) and good oral bioavailability (73.6%). In addition, rhodojaponin III was quickly eliminated after it was intravenously or orally administered, with half-life values of 0.19 and 0.76 h, respectively. After oral administration, it was widely distributed in tissues including kidney, lung, heart, spleen and thymus, but had extremely low concentrations in liver and brain[1]. R-III strongly inhibited Sf9 cells proliferation with a time- and dose-dependent manner. R-III induced a significant dose-dependent (1, 10, 100, 200 μg/mL) increase in [Ca2+](i) and pH(i) of Sf9 cells in presence of Ca2+-containing solution (Hanks) and an irreversible decrease in the absence of extra cellular Ca2+[2]. R-III showed an almost 30 times higher contact toxicity against third instars than for fifth instars, and the median lethal dose (LD50) values for topical application were 1.18 and 34.09 mg/kg at 72 h after treatment respectively. R-III disrupted the development of larvae to pupae or adults with median concentration for inhibiting growth (IC50) values of only 1.36 mg/L for third instars and 11.28 mg/L for fifth instars[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.71mL 0.54mL 0.27mL |
13.57mL 2.71mL 1.36mL |
27.14mL 5.43mL 2.71mL |
| 参考文献 |
|---|