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/ 降钙素基因相关肽受体 / Rat CGRP-(8-37) TFA salt

Rat CGRP-(8-37) TFA salt {[allProObj[0].p_purity_real_show]}

货号：A1159618

Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.

Rat CGRP-(8-37) TFA salt 化学结构 CAS号：N/A
Rat CGRP-(8-37) TFA salt 化学结构
CAS号：N/A
Rat CGRP-(8-37) TFA salt 3D分子结构
CAS号：N/A
Rat CGRP-(8-37) TFA salt 化学结构 CAS号：N/A
Rat CGRP-(8-37) TFA salt 3D分子结构 CAS号：N/A
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Rat CGRP-(8-37) TFA salt 纯度/质量文件 产品仅供科研

货号：A1159618 标准纯度： {[allProObj[0].p_purity_real_show]}
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Rat CGRP-(8-37) TFA salt 生物活性

描述 Rat CGRP-(8-37) TFA salt, a cholestanol-conjugated antagonist, accumulated in CLR(calcitonin receptor-like receptor)-containing endosomes and selectively inhibited CLR signaling in endosomes. CGRP8-37-cholestanol, but not unconjugated CGRP8-37, prevented sustained neuronal excitation. When injected intrathecally to mice, CGRP8-37-cholestanol inhibited nociceptive responses to intraplantar injection of capsaicin, formalin, or complete Freund's adjuvant more effectively than unconjugated CGRP8-37[3]. CGRP(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor and is a highly selective CGRP receptor antagonist. CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min[4]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[5].

Rat CGRP-(8-37) TFA salt 参考文献

[1]Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75.

[2]Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30.

[3]Yarwood RE, Imlach WL, Lieu T, et al. Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission. Proc Natl Acad Sci U S A. 2017;114(46):12309‐12314

[4]Bennett AD, Chastain KM, Hulsebosch CE. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chronic central pain. Pain. 2000;86(1-2):163‐175

[5]Yu LC, Hansson P, Lundeberg T. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawal responses in rats [published correction appears in Brain Res 1994 Dec 15;666(2):295]. Brain Res. 1994;653(1-2):223‐230

Rat CGRP-(8-37) TFA salt 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.31mL

0.06mL

0.03mL

1.54mL

0.31mL

0.15mL

3.08mL

0.62mL

0.31mL

Rat CGRP-(8-37) TFA salt 技术信息

CAS号N/A
分子式C140H225F3N42O43
分子量 3241.54
SMILES Code O=C([C@H]([C@H](O)C)NC([C@@H](N)C(C)C)=O)N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(N[C@](C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)([C@H](O)C)[H])=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
MDL No. N/A
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

Tags: Rat CGRP-(8-37) TFA salt |Rat CGRP-(8-37) TFA salt | N/A | 降钙素基因相关肽受体 | Rat CGRP-(8-37) TFA salt 纯度/质量文件 | Rat CGRP-(8-37) TFA salt 生物活性 | Rat CGRP-(8-37) TFA salt 参考文献 | Rat CGRP-(8-37) TFA salt 实验方案 | Rat CGRP-(8-37) TFA salt 技术信息

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