Zavegepant is a highly potent, selective and structurally unique small molecule CGRP receptor antagonist.

BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.

MK-3207 is a potent and orally bioavailable CGRP receptor antagonist (IC50= 0.12 nM; Ki value= 0.024 nM), showing highly selective versus human AM1, AM2, CTR, and AMY3.

Galcanezumab是一种人源化IgG4单克隆抗体，通过与CGRP结合来阻止其与受体结合。Galcanezumab具有用于偏头痛预防的潜力。

Fremanezumab是一种人源化IgG2单克隆抗体，通过与CGRP结合来阻止其与受体结合。Fremanezumab具有用于偏头痛预防的潜力。

SUN-B 8155 is a non-peptide calcitonin agonist.

PHM 27 (human) is a potent agonist for the human calcitonin receptor with EC50 of 11 nM.