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炔雌醚 /Quinestrol {[allProObj[0].p_purity_real_show]}

货号:A786551 同义名: 炔雌醇环戊醚 / W-3566;Ethynyl Estradiol-3-cyclopentyl ether

Quinestrol is a synthetic estrogen which is used in hormone replacement therapy.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Quinestrol 化学结构 CAS号:152-43-2
Quinestrol 化学结构
CAS号:152-43-2
Quinestrol 3D分子结构
CAS号:152-43-2
Quinestrol 化学结构 CAS号:152-43-2
Quinestrol 3D分子结构 CAS号:152-43-2
规格 价格 会员价 库存 数量
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Quinestrol 纯度/质量文件 产品仅供科研

货号:A786551 标准纯度: {[allProObj[0].p_purity_real_show]}
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Quinestrol 生物活性

描述 Quinestrol is a synthetic estrogen, used in hormone replacement therapy, and occasionally to treat breast cancer and prostate cancer. The weight of epididymides and seminal vesicles decreased significantly on days 8 and 22 in quinestrol/DES-treated (Diethylstilbestrol) mice, with extensive histological changes in the seminiferous tubules. The anti-fertility effects on male mice given quinestrol were of shorter duration than for those receiving DES at the dose of 1 mg/kg body weight[3]. Quinestrol causes reversible toxic effects in the form of oxidative stress, increased lytic enzyme activity and decreased steroidogenesis which may further lead to testicular damage thereby inhibiting reproductive function[4]. Normal male vocal behavior during sexual interactions could be retained or even reinforced after quinestrol treatment. The treated male mice were more attractive to the female mice than the controls[5]. The testicular weight and seminiferous tubular area gradually declined with increasing dosages of quinestrol to 50 and 100mg/kg. Rarefied germ cells showed irregular distributions in the seminiferous tubules of mice treated with 50 and 100mg/kg quinestrol. The number of germ cells expressing caspase-3, p53, Bax and FasL significantly increased whereas cells expressing Bcl-2 significantly decreased in groups treated with 50 and 100mg/kg quinestrol compared with the control. Quinestrol stimulates oxidative stress to induce apoptosis in spermatogenic cells through the mitochondrial and death receptor pathways in adult male mice[6].

Quinestrol 参考文献

[1]Chen Y, Su QQ, et al. Effects of quinestrol on the vocal behavior of mice during courtship interactions. Physiol Behav. 2017 May 1;173:216-222.

[2]Li J, Chen F, et al. Quinestrol induces spermatogenic apoptosis in vivo via increasing pro-apoptotic proteins in adult male mice. Tissue Cell. 2014 Oct;46(5):318-25.

[3]Liu M, Luo R, Wang H, Cao G, Wang Y. Recovery of fertility in quinestrol-treated or diethylstilbestrol-treated mice: Implications for rodent management. Integr Zool. 2017 May;12(3):250-259

[4]Sidhu A, Singla N, Lonare M, Mahal AK. Effect of quinestrol on body weight, vital organs, biochemicals and genotoxicity in adult male lesser bandicoot rat, Bandicota bengalensis. Pestic Biochem Physiol. 2020 May;165:104544

[5]Chen Y, Su QQ, Liu QS. Effects of quinestrol on the vocal behavior of mice during courtship interactions. Physiol Behav. 2017 May 1;173:216-222

[6]Li J, Chen F, Li C, Chen Y. Quinestrol induces spermatogenic apoptosis in vivo via increasing pro-apoptotic proteins in adult male mice. Tissue Cell. 2014 Oct;46(5):318-25

Quinestrol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.72mL

2.74mL

1.37mL

27.43mL

5.49mL

2.74mL

Quinestrol 技术信息

CAS号152-43-2
分子式C25H32O2
分子量 364.52
别名 炔雌醇环戊醚 ;W-3566;Ethynyl Estradiol-3-cyclopentyl ether;Parke Davis Brand of Quinestrol ;Estradiol 3 Cyclopentyl Ether;Ethinyl;Eston;Plestrovis;Estrovister;Quinestrolum;Estrovis;EE2CPE;Ethinylestradiol 3-cyclopentyl ether
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 250 mg/mL(685.83 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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