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Quercetin

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Chemical Structure| 117-39-5 同义名 : Sophoretin;C.I. 75720;Xanthaurine.;Quertine;Quercetol;Quercetine;NSC 9219;NCI-C60106;Meletin;Kvercetin;NSC 9221
CAS号 : 117-39-5
货号 : A292006
分子式 : C15H10O7
纯度 : 97%
分子量 : 302.236
MDL号 : MFCD00006828
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(347.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 15 mg/mL(49.63 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：

2% DMSO+30% PEG 300+2% Tween 80+water 6 mg/mL

生物活性
靶点

  • p110γ

    PI3Kγ, IC50:2.4 μM

  • p110β

    PI3Kβ, IC50:5.4 μM

  • p110δ

    PI3Kδ, IC50:3.0 μM

  • PKC

  • Src
描述 Quercetin, recognized for its presence in various dietary sources as a natural flavonoid, serves dual roles both as a stimulator of recombinant SIRT1 and as an inhibitor of PI3K, exhibiting IC50 values between 2.4 and 5.4 μM across different PI3K isoforms[1]. Quercetin GMP, which is Quercetin produced under Good Manufacturing Practice (GMP) guidelines, serves as an auxiliary reagent in cell therapy manufacturing, leveraging its status as a flavonoid antioxidant, PI3K inhibitor, and SIRT1 activator[1].[2].[3].[4].[5].[6].
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
HEK293 FS cells Function assay Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=0.68 μM 20731357
HT22 cells Function assay Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells, EC50=2.98 μM 16392814
HT22 cells Function assay Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay, EC50=3.13 μM 24602904
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.09mL

6.62mL

3.31mL
参考文献

[1]Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80.

[2]Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81.

[3]Zhou Y, et al. The Effect of Quercetin on the Osteogenesic Differentiation and Angiogenic Factor Expression of Bone Marrow-Derived Mesenchymal Stem Cells. PLoS One. 2015 Jun 8;10(6):e0129605.

[4]Woo JT, et al. Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biol Pharm Bull. 2004 Apr;27(4):504-9.

[5]Kim YJ, et al. Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Biochem Pharmacol. 2006 Nov 15;72(10):1268-78.

[6]Pang XG, et al. Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. Biomed Res Int. 2018 Mar 15;2018:4178021.