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盐酸吡多胺 /Pyridoxamine 2HCl {[allProObj[0].p_purity_real_show]}

货号:A141540 同义名: Pyridoxamine (hydrochloride);Pyridoxylamine

Pyridoxylamine 2HCl is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor.

Pyridoxamine 2HCl 化学结构 CAS号:524-36-7
Pyridoxamine 2HCl 化学结构
CAS号:524-36-7
Pyridoxamine 2HCl 3D分子结构
CAS号:524-36-7
Pyridoxamine 2HCl 化学结构 CAS号:524-36-7
Pyridoxamine 2HCl 3D分子结构 CAS号:524-36-7
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Pyridoxamine 2HCl 纯度/质量文件 产品仅供科研

货号:A141540 标准纯度: {[allProObj[0].p_purity_real_show]}
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Pyridoxamine 2HCl 生物活性

描述 Pyridoxylamine 2HCl is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions. Pyridoxylamine limits the formation of CML ((carboxymethyl)lysine) and CEL (Nε-(carboxyethyl)lysine) and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats in vivo[1]. UV-Vis spectrophotometry and fluorescence were used to measure PDA (Pyridoxylamine) reactivity for 57 chemicals including anhydrides, aldehydes, and quinones where reaction rates ranged from 116 to 6.2 × 10(-6) M(-1) s(-1) for extreme to weak sensitizers, respectively. No reactivity towards PDA was observed with the thiol-selective sensitizers, non-sensitizers and prohaptens. The PDA rate constants correlated significantly with their respective murine local lymph node assay (LLNA) threshold EC3 values (R(2) = 0.76). The use of PDA serves as a simple, inexpensive amine based method that shows promise as a preliminary screening tool for electrophilic, amine-selective skin sensitizers[2].

Pyridoxamine 2HCl 参考文献

[1]Stitt A, Gardiner TA, Alderson NL, et al. The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes [published correction appears in Diabetes 2003 Jan;52(1):223. Anderson Nathan L [corrected to Alderson Nathan L]]. Diabetes. 2002;51(9):2826‐2832

[2]Chipinda I, Mbiya W, Adigun RA, et al. Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizers. Toxicology. 2014;315:102‐109

Pyridoxamine 2HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.15mL

0.83mL

0.41mL

20.74mL

4.15mL

2.07mL

41.47mL

8.29mL

4.15mL

Pyridoxamine 2HCl 技术信息

CAS号524-36-7
分子式C8H14Cl2N2O2
分子量 241.115
别名 Pyridoxamine (hydrochloride);Pyridoxylamine
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 115 mg/mL(476.95 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 120 mg/mL(497.69 mM),配合低频超声助溶

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