Proflavine Hemisulfate | 原黄素半硫酸盐 | 3,6-Diaminoacridine hemisulfate | Anti-microbial Agent

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硫酸原黄素 /Proflavine Hemisulfate {[allProObj[0].p_purity_real_show]}

货号：A656336 同义名： 原黄素半硫酸盐 / 3,6-Diaminoacridine hemisulfate;Proflavin hemisulfate

Proflavine hemisulfate is an acridine-derived fluorescent contrast and disinfectant agent potentially used for cellular imaging and antiseptic purposes.

Proflavine Hemisulfate 化学结构
CAS号：1811-28-5

Proflavine Hemisulfate 3D分子结构
CAS号：1811-28-5

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Proflavine Hemisulfate 纯度/质量文件产品仅供科研

货号：A656336 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Proflavine Hemisulfate 生物活性

描述

Proflavine hemisulfate is an Acridine derivative, which is a slow-acting disinfectant with bacteriostatic action against many Gram-positive bacteria but less effective against Gram-negative organisms^[2]. Moreover, the bacteriostatic agent, proflavine, preferentially blocked a subset of inward rectifier K+ (Kir) channels^[3]. Mutants resistant to 1. 0 mM PF (Proflavine) were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells^[4]. In comparing proflavine-light and placebo-light treatment, 0. 1% proflavine administration twice daily for 5 days had a significant effect in suppressing herpetic eye disease, but 0. 05% proflavine was less effective^[5]. Proflavine hemisulfate, an acridine-derived fluorescent dye, can be used as a rapid stain for cytologic examination of biological specimens^[6].

Proflavine Hemisulfate 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02494310	Neoplasia of the Uterine Cervi... 展开 >>x Cancer Prevention Cervical Intraepithelial Neoplasia 收起 <<	Not Applicable	Completed	-	-
NCT02420665	Cervical Cancer	Early Phase 1	Active, not recruiting	September 2025	United States, Texas ... 展开 >> Lyndon B. Johnson General Hospital Houston, Texas, United States, 77026 University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT02335372	Cervical Cancer	Not Applicable	Active, not recruiting	June 2020	Brazil ... 展开 >> Barretos Cancer Hospital Barretos, Brazil, 14784-400 收起 <<

Proflavine Hemisulfate 参考文献

[1]Prieto SP, Powless AJ, et al. Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology. PLoS One. 2015 May 11;10(5):e0125598.

[2]Pridgeon JW, Klesius PH, Yildirim-Aksoy M. Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. Vaccine. 2013 Apr 26;31(18):2222-30. doi: 10.1016/j.vaccine.2013.03.004. Epub 2013 Mar 13. PMID: 23499519.

[3]Inanobe A, Itamochi H, Kurachi Y. Kir Channel Blockages by Proflavine Derivatives via Multiple Modes of Interaction. Mol Pharmacol. 2018 Jun;93(6):592-600. doi: 10.1124/mol.117.111377. Epub 2018 Apr 12. PMID: 29650538.

[4]McKellar RC, McKenzie CN, Kushner KJ. Correlation of resistance to proflavine and penicillin in Escherichia coli. Antimicrob Agents Chemother. 1976 Oct;10(4):765-7. doi: 10.1128/AAC.10.4.765. PMID: 791110; PMCID: PMC429826.

[5]Lanier JD, Whitcher JP, Dawson CR, Oh JO. Proflavine and light in the treatment of experimental herpetic ocular infections. Antimicrob Agents Chemother. 1974 Nov;6(5):613-9. doi: 10.1128/AAC.6.5.613. PMID: 15825315; PMCID: PMC444702.

[6]Prieto SP, Powless AJ, Boice JW, Sharma SG, Muldoon TJ. Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology. PLoS One. 2015 May 11;10(5):e0125598. doi: 10.1371/journal.pone.0125598. PMID: 25962131; PMCID: PMC4427403.

Proflavine Hemisulfate 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.25mL

0.65mL

0.33mL

16.27mL

3.25mL

1.63mL

32.54mL

6.51mL

3.25mL

Proflavine Hemisulfate 技术信息

CAS号	1811-28-5
分子式	C₁₃H₁₃N₃O₄S
分子量	307.325

别名	原黄素半硫酸盐 ;3,6-Diaminoacridine hemisulfate;Proflavin hemisulfate;Hemisulfate, Proflavine;Acridine, 3,6-Diamino;3,6 Diamino Acridine;3,6-Acridinediamine, sulfate (2:1);EINECS 217-320-3;Proflavine hemisulfate dihydrate;Proflavine hemisulphate
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

H₂O: 5 mg/mL(16.27 mM)

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02494310	Neoplasia of the Uterine Cervi... 展开 >>x Cancer Prevention Cervical Intraepithelial Neoplasia 收起 <<	Not Applicable	Completed	-	-
NCT02420665	Cervical Cancer	Early Phase 1	Active, not recruiting	September 2025	United States, Texas ... 展开 >> Lyndon B. Johnson General Hospital Houston, Texas, United States, 77026 University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT02335372	Cervical Cancer	Not Applicable	Active, not recruiting	June 2020	Brazil ... 展开 >> Barretos Cancer Hospital Barretos, Brazil, 14784-400 收起 <<
NCT02790853	Dysplasia Lip... 展开 >> and Oral Cavity Carcinoma Oral Disorder Premalignant Lesion 收起 <<	Early Phase 1	Recruiting	May 31, 2026	United States, Texas ... 展开 >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Ann M. Gillenwater 713-792-8841 Principal Investigator: Ann M. Gillenwater 收起 <<
NCT02095847	Uterine Cancer	Phase 2	Withdrawn	-	-
NCT02207959	Gastric Cancer	Phase 1	Terminated(PI left institution... 展开 >>) 收起 <<	-	United States, New York ... 展开 >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 收起 <<
NCT01269190	Oral Cavity Neoplasm	Early Phase 1	Recruiting	December 31, 2018	United States, Texas ... 展开 >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Ann M. Gillenwater 713-792-8841 Principal Investigator: Ann M. Gillenwater 收起 <<
NCT02206048	Cervix Carcinoma	Not Applicable	Active, not recruiting	October 2019	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT02714439	Malignant Neoplasms of Female ... 展开 >>Genital Organs 收起 <<	Early Phase 1	Active, not recruiting	July 2020	United States, Texas ... 展开 >> University of Texas Medical Branch Cancer Stop McAllen Clinic McAllen, Texas, United States, 78501 收起 <<
NCT01456143	-		Terminated(PI left, study to b... 展开 >>e re-open with new PI, no planned data analysis) 收起 <<	-	-
NCT01456143	Squamous Cell Carcinoma ... 展开 >> Neoplasia Head and Neck Cancer 收起 <<	Not Applicable	Terminated(PI left, study to b... 展开 >>e re-open with new PI, no planned data analysis) 收起 <<	-	United States, New York ... 展开 >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10017 收起 <<
NCT01384695	GERD Barrett'... 展开 >>s Esophagus 收起 <<	Early Phase 1	Terminated(Low/no enrollment. ... 展开 >>No subjects were enrolled over the past year.) 收起 <<	-	United States, New York ... 展开 >> Mount Sinai Medical Center New York, New York, United States, 10029 收起 <<
NCT01384240	Colon Polyps ... 展开 >>Colonic Dysplasia Anal Dysplasia 收起 <<	Early Phase 1	Terminated(Study is closed as ... 展开 >>the PI transferred to another institution.) 收起 <<	-	United States, New York ... 展开 >> Mount Sinai Medical Center New York, New York, United States, 10029 收起 <<
NCT01384864	Barrett's Esophagus ... 展开 >> Intraepithelial Neoplasia 收起 <<	Early Phase 1	Completed	-	United States, New York ... 展开 >> Mount Sinai School of Medicine New York, New York, United States, 10029 收起 <<
NCT01384708	Squamous Cell Cancer	Early Phase 1	Completed	-	United States, New York ... 展开 >> Mount Sinai Medical Center New York, New York, United States, 10029 收起 <<
NCT02029937	Suspected or Known Squamous Ce... 展开 >>ll Neoplasia Prior History of Squamous Cell Dysplasia and /or Neoplasia 收起 <<	Phase 2	Recruiting	December 2020	United States, Texas ... 展开 >> Baylor College of Medicine Recruiting Houston, Texas, United States, 77030 Principal Investigator: Sharmila Anandasabapathy, MD China, Jilin First Hospital of Jilin University Recruiting Changchun, Jilin, China Contact: Fan Zhang fanzhangchina@163.com Principal Investigator: Hong Xu China Cancer Institute and Hospital, Chinese Academy of Medical Sciences (CICAMS) Recruiting Beijing, China Contact: Yu Xinying littlenewyxy@163.com Principal Investigator: Guiqi Wang 收起 <<
NCT01384227	Barrett's Esophagus	Early Phase 1	Completed	-	United States, New York ... 展开 >> Mount Sinai Medical Center New York, New York, United States, 10029 收起 <<
NCT02018367	Barrett's Esophagus	Phase 2	Recruiting	June 2019	United States, Texas ... 展开 >> Baylor College of Medicine Recruiting Houston, Texas, United States, 77030 Contact: Madeleine Allman, MPH 713-798-7585 madeleine.allman@bcm.edu 收起 <<

硫酸原黄素 /Proflavine Hemisulfate {[allProObj[0].p_purity_real_show]}

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Proflavine Hemisulfate 生物活性

Proflavine Hemisulfate 临床研究

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Proflavine Hemisulfate 实验方案

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硫酸原黄素 /Proflavine Hemisulfate {[allProObj[0].p_purity_real_show]}

Proflavine Hemisulfate 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Proflavine Hemisulfate 质控信息

Proflavine Hemisulfate 生物活性

Proflavine Hemisulfate 临床研究

Proflavine Hemisulfate 参考文献

Proflavine Hemisulfate 实验方案

Proflavine Hemisulfate 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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