产品说明书
Proflavine Hemisulfate
 |
同义名 : | 原黄素半硫酸盐 ;3,6-Diaminoacridine hemisulfate;Proflavin hemisulfate;Hemisulfate, Proflavine;Acridine, 3,6-Diamino;3,6 Diamino Acridine;3,6-Acridinediamine, sulfate (2:1);EINECS 217-320-3;Proflavine hemisulfate dihydrate;Proflavine hemisulphate |
| CAS号 : | 1811-28-5 | |
| 货号 : | A656336 | |
| 分子式 : | C13H13N3O4S | |
| 纯度 : | 97% | |
| 分子量 : | 307.325 | |
| MDL号 : | MFCD00149650 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 5 mg/mL(16.27 mM) |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Proflavine hemisulfate is an Acridine derivative, which is a slow-acting disinfectant with bacteriostatic action against many Gram-positive bacteria but less effective against Gram-negative organisms[2]. Moreover, the bacteriostatic agent, proflavine, preferentially blocked a subset of inward rectifier K+ (Kir) channels[3]. Mutants resistant to 1. 0 mM PF (Proflavine) were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells[4]. In comparing proflavine-light and placebo-light treatment, 0. 1% proflavine administration twice daily for 5 days had a significant effect in suppressing herpetic eye disease, but 0. 05% proflavine was less effective[5]. Proflavine hemisulfate, an acridine-derived fluorescent dye, can be used as a rapid stain for cytologic examination of biological specimens[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02494310 | Neoplasia of the Uterine Cervi... 展开 >>x Cancer Prevention Cervical Intraepithelial Neoplasia 收起 << | Not Applicable | Completed | - | - |
| NCT02420665 | Cervical Cancer | Early Phase 1 | Active, not recruiting | September 2025 | United States, Texas ... 展开 >> Lyndon B. Johnson General Hospital Houston, Texas, United States, 77026 University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 << |
| NCT02335372 | Cervical Cancer | Not Applicable | Active, not recruiting | June 2020 | Brazil ... 展开 >> Barretos Cancer Hospital Barretos, Brazil, 14784-400 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.25mL 0.65mL 0.33mL |
16.27mL 3.25mL 1.63mL |
32.54mL 6.51mL 3.25mL |
| 参考文献 |
|---|