盐酸普拉格雷 /Prasugrel HCl
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货号：A529076
同义名：
PCR 4099 hydrochloride;Prasugrel hydrochloride
Prasugrel HCl is a platelet inhibitor with IC50 value of 1.8 μM.
Prasugrel HCl 化学结构
Prasugrel HCl 3D分子结构
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Prasugrel HCl 纯度/质量文件 产品仅供科研
货号：A529076
标准纯度：
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Prasugrel HCl 质控信息
Prasugrel HCl 生物活性
描述
Prasugren HCl, irreversibly inhibits the P2Y12 receptors, inhibiting ADP-dependent platelet activation[3] [4] [5] [6] [7]
Prasugrel HCl 参考文献
[1] Baker WL, White CM. Role of prasugrel, a novel P2Y(12) receptor antagonist, in the management of acute coronary syndromes. Am J Cardiovasc Drugs. 2009;9(4):213-29.
[2] Sugidachi A, Ogawa T, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51. Epub 2007 Apr 19.
[3] Conran N, Rees DC. Prasugrel hydrochloride for the treatment of sickle cell disease. Expert Opin Investig Drugs. 2017 Jul;26(7):865-872
[4] Khan MS, Memon MM, Usman MS, Alnaimat S, Khan SU, Khan AR, Yamani N, Fugar S, Mookadam F, Krasuski RA, Doukky R. Prasugrel vs. Ticagrelor for Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis. Am J Cardiovasc Drugs. 2019 Oct;19(5):465-476
[5] Xia P, He C, Chen L, Zou L, Sun S, Cui P, Wang W. Efficacy and safety of prasugrel therapy for intracranial aneurysms with endovascular treatment: A meta-analysis. J Neurol Sci. 2019 Feb 15;397:174-178
[6] Gunarathne A, Hussain S, Gershlick AH. Prasugrel hydrochloride for the treatment of acute coronary syndrome patients. Expert Rev Cardiovasc Ther. 2016 Nov;14(11):1215-1226
[7] Spartalis M, Tzatzaki E, Spartalis E, Damaskos C, Athanasiou A, Moris D, Politou M. The role of prasugrel in the management of acute coronary syndromes: a systematic review. Eur Rev Med Pharmacol Sci. 2017 Oct;21(20):4733-4743
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Prasugrel HCl 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.44mL
0.49mL
0.24mL
12.20mL
2.44mL
1.22mL
24.40mL
4.88mL
2.44mL
Prasugrel HCl 技术信息
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