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描述 | Prasugren HCl, irreversibly inhibits the P2Y12 receptors, inhibiting ADP-dependent platelet activation[3]. Prasugrel might have a better efficacy profile than ticagrelor in patients with ACS (acute coronary syndrome) undergoing PCI (percutaneous coronary intervention) [4]. In antiplatelet therapy after aneurysmal interventional therapy, the second generation of P2Y12 adenosine receptor antagonist prasugrel can significantly reduce the risk of thrombosis without increasing the risk of bleeding[5]. Laboratory studies and early phase clinical trials show prasugrel has a faster onset of action, is more potent and has reduced inter-patient response variability compared to clopidogrel[6]. Prasugrel and ticagrelor are more efficacious than clopidogrel in reducing the occurrence of non-fatal myocardial infarction, stroke, or cardiovascular (CV) death but they have also an increased risk of major bleeding in comparison to clopidogrel[7]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.44mL 0.49mL 0.24mL |
12.20mL 2.44mL 1.22mL |
24.40mL 4.88mL 2.44mL |
CAS号 | 389574-19-0 |
分子式 | C20H21ClFNO3S |
分子量 | 409.902 |
别名 | PCR 4099 hydrochloride;Prasugrel hydrochloride |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place,Inert atmosphere,2-8°C |
溶解方案 |
DMSO: 40 mg/mL(97.58 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |