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氯磷啶 /Pralidoxime chloride {[allProObj[0].p_purity_real_show]}

货号:A307244 同义名: 氯解磷定;1-甲基吡啶-2-醛肟氯鎓盐 / 2-PAM chloride;Pralidoxime (chloride)

Pralidoxime chloride is an AChE reactivator, used as an antidote to organophosphate pesticides and chemicals.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Pralidoxime chloride 化学结构 CAS号:51-15-0
Pralidoxime chloride 化学结构
CAS号:51-15-0
Pralidoxime chloride 3D分子结构
CAS号:51-15-0
Pralidoxime chloride 化学结构 CAS号:51-15-0
Pralidoxime chloride 3D分子结构 CAS号:51-15-0
规格 价格 会员价 库存 数量
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Pralidoxime chloride 纯度/质量文件 产品仅供科研

货号:A307244 标准纯度: {[allProObj[0].p_purity_real_show]}
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Pralidoxime chloride 生物活性

描述 Pralidoxime Chloride is an oxime AChE (acetylcholinesteras) reactivator. Pralidoxime 100μM reversed human BuChE inhibition by parathion and by paraoxon by about 50%. Moreover, pralidoxime-induced reactivation of BuChE (butyrylcholinesterase) is highly variable, according to the dose, organophosphorus involved, and the individual poisoned[3]. In fact, a decrease in AChE activity of ~10 to 15% percent activity was observed between the 2-PAM Cl (Pralidoxime Chloride)-treated and untreated aldicarb and methomyl challenged gpAChE-R[4].

Pralidoxime chloride 参考文献

[1]Lucyk S, Vilensky D, et al. Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicol Sci. 2014 Apr;138(2):482.

[2]Rios JC, Repetto G, et al. High concentrations of pralidoxime are needed for the adequate reactivation of human erythrocyte acetylcholinesterase inhibited by dimethoate in vitro. Toxicol In Vitro. 2005 Oct;19(7):893-7.

[3]Konickx LA, Worek F, Jayamanne S, Thiermann H, Buckley NA, Eddleston M. Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicol Sci. 2013 Dec;136(2):274-83.

[4]Brittain MK, McGarry KG, Moyer RA, Babin MC, Jett DA, Platoff GE Jr, Yeung DT. Efficacy of Recommended Prehospital Human Equivalent Doses of Atropine and Pralidoxime Against the Toxic Effects of Carbamate Poisoning in the Hartley Guinea Pig. Int J Toxicol. 2016 May;35(3):344-57.

Pralidoxime chloride 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.79mL

1.16mL

0.58mL

28.97mL

5.79mL

2.90mL

57.93mL

11.59mL

5.79mL

Pralidoxime chloride 技术信息

CAS号51-15-0
分子式C7H9ClN2O
分子量 172.612
别名 氯解磷定;1-甲基吡啶-2-醛肟氯鎓盐;1-甲基吡啶-2-醛肟氯盐;吡啶醛肟甲氯 ;2-PAM chloride;Pralidoxime (chloride);2-PAM;2-PAM (chloride)
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 20 mg/mL(115.87 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(579.33 mM)

动物实验配方
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