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聚维酮碘 /Poly(vinylpyrrolidone)–Iodine complex {[allProObj[0].p_purity_real_show]}

货号:A766302 同义名: 聚乙烯吡咯烷酮碘;聚乙烯吡酮磺 / Povidone iodine;iodopovidone

Poly(vinylpyrrolidone)–Iodine complex是一种用于手术前后皮肤消毒的抗菌剂,可杀死 MRSA 和 MSSA 菌株,其 MICs 值分别为 31.25 mg/L 和7.82 mg/L。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Poly(vinylpyrrolidone)–Iodine complex 化学结构 CAS号:25655-41-8
Poly(vinylpyrrolidone)–Iodine complex 化学结构
CAS号:25655-41-8
Poly(vinylpyrrolidone)–Iodine complex 3D分子结构
CAS号:25655-41-8
Poly(vinylpyrrolidone)–Iodine complex 化学结构 CAS号:25655-41-8
Poly(vinylpyrrolidone)–Iodine complex 3D分子结构 CAS号:25655-41-8
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Poly(vinylpyrrolidone)–Iodine complex 纯度/质量文件 产品仅供科研

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Poly(vinylpyrrolidone)–Iodine complex 生物活性

描述 Povidone Iodine (PVP-I) is an antiseptic used for skin disinfection before and after surgery. Povidone iodine displays excellent antibacterial activity which can against MRSA (meticillin-resistant) and MSSA (meticillin-susceptible) strains with MICs (minimum inhibitory concentration) of 31.25 mg/L and 7.82 mg/L, respectively. Treatment of the cells with Povidone iodine (PVP-I) at a dilution of 1:32 causes a sharp reduction in cell viability by 90-95% on all testing cell lines[3]. Povidone iodine has many characteristics that position it extraordinarily well for wound healing, including its broad antimicrobial spectrum, lack of resistance, efficacy against biofilms, good tolerability and its effect on excessive inflammation.[4]. SARS-CoV-2 virus was completely inactivated by PVP-I oral antiseptic rinse in vitro, at the lowest concentration of 0.5 % and at the lowest contact time of 15 seconds[5]. Nasal and oral PVP-I antiseptic solutions are effective at inactivating the SARS-CoV-2 at a variety of concentrations after 60-second exposure times[6].

Poly(vinylpyrrolidone)–Iodine complex 参考文献

[1]Sato S, Miyake M, et al. Povidone-iodine-induced cell death in cultured human epithelial HeLa cells and rat oral mucosal tissue. Drug Chem Toxicol. 2014 Jul;37(3):268-75.

[2]Akcay E, Ersahin Y, et al. Neurotoxic effect of povidone-iodine on the rat spine using a laminectomy-durotomy model. Childs Nerv Syst. 2012 Dec;28(12):2071-5.

[3]Zisi AP, Exindari MK, Siska EK, Koliakos GG. Iodine-lithium-alpha-dextrin (ILαD) against Staphylococcus aureus skin infections: a comparative study of in-vitro bactericidal activity and cytotoxicity between ILαD and povidone-iodine. J Hosp Infect. 2018 Feb;98(2):134-140

[4]Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA. Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg. 2017 Aug;44:260-268

[5]Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Comparison of In Vitro Inactivation of SARS CoV-2 with Hydrogen Peroxide and Povidone-Iodine Oral Antiseptic Rinses. J Prosthodont. 2020 Aug;29(7):599-603

[6]Pelletier JS, Tessema B, Frank S, Westover JB, Brown SM, Capriotti JA. Efficacy of Povidone-Iodine Nasal and Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2). Ear Nose Throat J. 2021 Apr;100(2_suppl):192S-196S

Poly(vinylpyrrolidone)–Iodine complex 技术信息

CAS号25655-41-8
分子式(C6H9NO)x.xI2
分子量
别名 聚乙烯吡咯烷酮碘;聚乙烯吡酮磺;聚乙烯吡咯烷酮碘络合物 ;Povidone iodine;iodopovidone;Polyvinylpyrrolidone-Iodine;NSC 26245;Isodine;PVP-I;PVP iodine;Betadine
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature

溶解方案

DMSO: 14 mg/mL,配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 2 mg/mL,配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
配制的工作液建议现用现配,短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
动物实验配方
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