Phillygenin is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation .
Phillygenin (Forsythigenol) is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation. PHI (Phillygenin) attenuates CCl4(10% carbon tetrachloride)-induced liver fibrosis partly via modulating inflammation and gut microbiota[3]. PHI inhibited the inflammation and apoptosis of pulmonary epithelial cells by activating PPARγ signaling via downregulating MMP8[4]. Phillygenin inhibited the growth of SH-1-V1 cells and exhibited an IC50 of 6 µM. Phillygenin inhibited in vitro and in vivo cancer cell growth in drug-resistant human esophageal cancer cells, and these effects were mediated via apoptosis, ROS generation, mitochondrial membrane potential loss, and activation of the NF-kB signalling pathway[5]. PHI could inhibit the proliferation, migration, and EMT (epithelial-mesenchymal transition) of pancreatic cancer cells (PANC-1 and SW1990) and induce its apoptosis[6].
179068-02-1 PHCCC
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